SCHEMBL5250768

SCHEMBL5250768

NNC(=O)C=Cc1cccc(N)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.67
CYP19A1 P11511 2/20 0.52
MAOA P21397 1/20 0.52
MAOB P27338 1/20 0.52
HDAC3 O15379 3/20 0.47
HDAC1 Q13547 3/20 0.47
KDM1A O60341 1/20 0.47
MMP1 P03956 4/20 0.46
MMP2 P08253 4/20 0.46
MMP9 P14780 4/20 0.46
MAPT P10636 2/20 0.46
NPC1 O15118 1/20 0.46
GFER P55789 1/20 0.46
HDAC2 Q92769 3/20 0.46
HDAC8 Q9BY41 3/20 0.46
HDAC4 P56524 2/20 0.46
HDAC6 Q9UBN7 2/20 0.46
HDAC7 Q8WUI4 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC11 Q96DB2 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5250765 1.00 NPSR1 (0.67) NPSR1CYP19A1MAOAMAOBHDAC3
SCHEMBL458024 0.83 MMP1 (0.67) MAOBMMP1MMP2MMP9
SCHEMBL458025 0.83 MMP1 (0.67) MAOBMMP1MMP2MMP9
SCHEMBL29619510 0.82 NPSR1 (0.76) NPSR1CYP19A1MAOAMAOBKDM1A
SCHEMBL28872986 0.81 MMP1 (0.57) NPSR1MAOAMAOBHDAC3HDAC1
SCHEMBL28294355 0.81 CA12 (0.59) MAOAMAOBHDAC3HDAC1MMP1
SCHEMBL1003575 0.80 NPSR1 (1.00) NPSR1CYP19A1MAOAMAOBHDAC3
SCHEMBL29777960 0.80 NPSR1 (1.00) NPSR1CYP19A1MAOAMAOBHDAC3
SCHEMBL1000884 0.80 NPSR1 (1.00) NPSR1CYP19A1MAOAMAOBHDAC3
SCHEMBL31480914 0.80 NPSR1 (0.73) NPSR1CYP19A1MAOAMAOBKDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1542680-B1 1, 4, 5-SUBSTITUTED 1, 2-DIHYDRO-PYRAZOL-3-ONE AND 3-ALKOXY-1H-PYRAZOLE DERIVATIVES AS TNF-ALPHA AND INTERLEUKIN LOWERING AGENTS FOR THE TREATMENT OF INFLAMMATIONS AMGEN INC (US) 2007-03-07 EP disclosed