SCHEMBL28872986

SCHEMBL28872986

Cc1cccc(C=CC(=O)NN)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 7/20 0.57
MMP2 P08253 7/20 0.57
MMP9 P14780 7/20 0.57
MAOB P27338 3/20 0.57
MAOA P21397 2/20 0.57
EGFR P00533 2/20 0.57
ALOX5 P09917 1/20 0.47
PTGS1 P23219 1/20 0.47
PTGS2 P35354 1/20 0.47
HTT P42858 1/20 0.47
MAPT P10636 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
TP53 P04637 1/20 0.47
SLC6A19 Q695T7 1/20 0.47
HDAC3 O15379 1/20 0.46
HDAC1 Q13547 1/20 0.46
FBP1 P09467 1/20 0.46
KDM4E B2RXH2 1/20 0.46
MEN1 O00255 1/20 0.46
ALDH1A1 P00352 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8302981 0.85 HDAC1 (0.65) MMP1MMP2MMP9MAOBMAOA
SCHEMBL5435234 0.81 MMP1 (0.52) MMP1MMP2MMP9MAOBMAOA
SCHEMBL5435236 0.81 MMP1 (0.52) MMP1MMP2MMP9MAOBMAOA
SCHEMBL458025 0.81 MMP1 (0.67) MMP1MMP2MMP9MAOB
SCHEMBL5250768 0.81 NPSR1 (0.67) MMP1MMP2MMP9MAOBMAOA
SCHEMBL5250765 0.81 NPSR1 (0.67) MMP1MMP2MMP9MAOBMAOA
SCHEMBL458024 0.81 MMP1 (0.67) MMP1MMP2MMP9MAOB
SCHEMBL1124583 0.81 MAOA (0.58) MMP1MMP2MMP9MAOBMAOA
SCHEMBL1124587 0.81 MAOA (0.58) MMP1MMP2MMP9MAOBMAOA
SCHEMBL5599099 0.80 CYP1A2 (0.61) MMP1MMP2MMP9MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117623968-A Method for preparing N-substituted lactamide by catalyzing polylactic acid aminolysis with ionic liquid 中国科学院化学研究所 2024-03-01 CN disclosed
CN-109761941-A 2- (benzofuran -7- oxygroup)-N '-substituted aryl/alkyl acetoacetates hydazone derivative and the preparation method and application thereof 河北大学 2019-05-17 CN disclosed