Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.45 |
| ▸ | HTR1A | P08908 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252279 | 0.90 | HTR1A (0.43) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL2985074 | 0.89 | CTSS (0.47) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL2981140 | 0.86 | CTSS (0.55) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL2978841 | 0.84 | CTSS (0.49) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL2979193 | 0.83 | CTSS (0.59) | HTR2AHTR1ADRD2CTSS | |
| SCHEMBL5256704 | 0.80 | CTSS (0.47) | DRD2CTSS | |
| SCHEMBL2981307 | 0.80 | HTR2A (0.47) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL5787937 | 0.75 | CTSS (0.72) | CTSS | |
| SCHEMBL14107676 | 0.74 | CTSS (0.58) | CTSS | |
| SCHEMBL5788301 | 0.74 | CTSS (0.72) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309591-B1 | SUBSTITUTED PYRAZOLES | ORTHO MCNEIL PHARM INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-1315491-B1 | USE OF SUBSTITUTED PYRAZOLES FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ALLERGIES | ORTHO MCNEIL PHARM INC (US) | 2006-08-09 | — | — | EP | claimed |