Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.41 |
| ▸ | MMP12 | P39900 | 3/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP7 | P09237 | 2/20 | 0.40 |
| ▸ | MMP10 | P09238 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2517945 | 1.00 | USP30 (0.51) | USP30GPR119LIPEKCNH2SCN5A | |
| SCHEMBL2520347 | 0.83 | USP30 (0.53) | USP30GPR119LIPEKCNH2SCN5A | |
| SCHEMBL2516381 | 0.83 | USP30 (0.53) | USP30GPR119LIPEKCNH2SCN5A | |
| SCHEMBL2515969 | 0.78 | HDAC3 (0.45) | HDAC3HDAC1HDAC2EPHX2NR1H4 | |
| SCHEMBL2516384 | 0.73 | USP30 (0.42) | USP30GPR119LIPEKCNH2SCN5A | |
| SCHEMBL21819347 | 0.72 | GPR119 (0.55) | GPR119LIPEEPHX2NR1H4 | |
| SCHEMBL16032847 | 0.71 | USP30 (0.60) | USP30GPR119ADAM17MMP12MMP3 | |
| SCHEMBL16032849 | 0.71 | USP30 (0.60) | USP30GPR119ADAM17MMP12MMP3 | |
| SCHEMBL20757381 | 0.70 | LIPE (0.56) | GPR119LIPEKCNH2SCN5ASCN9A | |
| SCHEMBL2515972 | 0.70 | SSTR4 (0.47) | LIPEKCNH2SCN5ASCN9AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748980-A1 | PYRROLIDINE DERIVATIVES AS CB1-RECEPTOR ANTAGONISTS | TANABE SEIYAKU CO., LTD. (JP) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005115977-A1 | PYRROLIDINE DERIVATIVES AS CB1-RECEPTOR ANTAGONISTS | TANABE SEIYAKU CO., LTD. (JP) | 2005-12-08 | — | — | WO | disclosed |