Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16467020 | 0.85 | OPRK1 (0.50) | OPRK1ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL16467021 | 0.83 | ALDH1A1 (0.50) | OPRK1ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL3541202 | 0.81 | MAPT (0.58) | OPRK1ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL801074 | 0.81 | ALDH1A1 (0.59) | OPRK1ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL5252865 | 0.81 | OPRK1 (0.46) | OPRK1ALDH1A1MAPTCYP2C9CYP2C19 | |
| SCHEMBL3544895 | 0.79 | OPRK1 (0.47) | OPRK1ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL3544900 | 0.79 | OPRK1 (0.47) | OPRK1ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL13009734 | 0.79 | OPRK1 (0.52) | OPRK1ALDH1A1MAPK1HTTMAPT | |
| SCHEMBL5249138 | 0.79 | MAPT (0.67) | ALDH1A1MAPK1MAPTPOLBL3MBTL1 | |
| SCHEMBL25199087 | 0.78 | HTT (0.64) | OPRK1ALDH1A1MAPK1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101115731-A | Oxadiazole derivatives as DGAT inhibitors | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | CN | disclosed |
| EP-1833806-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006064189-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |