SCHEMBL5252736

SCHEMBL5252736

NC(=O)CN(N)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 3/20 0.43
ALDH1A1 P00352 5/20 0.41
POLB P06746 2/20 0.41
TSHR P16473 2/20 0.41
KMT2A Q03164 2/20 0.41
NPC1 O15118 1/20 0.41
HTT P42858 1/20 0.41
RAB9A P51151 1/20 0.41
GLA P06280 1/20 0.41
CYP3A4 P08684 2/20 0.39
CYP2C19 P33261 2/20 0.39
PARP1 P09874 1/20 0.39
MAPT P10636 1/20 0.39
RECQL P46063 1/20 0.39
BLM P54132 1/20 0.39
PMP22 Q01453 1/20 0.39
HSD17B10 Q99714 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
SMN1; SMN2 Q16637 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8781767 0.85 ALDH1A1 (0.44) NPSR1ALDH1A1POLBTSHRKMT2A
SCHEMBL680475 0.84 NPSR1 (0.44) NPSR1ALDH1A1POLBTSHRKMT2A
Hydrochloric Acid SCHEMBL4501078 0.83 NPSR1 (0.43) NPSR1ALDH1A1POLBTSHRKMT2A
SCHEMBL1561383 0.80 NPSR1 (0.44) NPSR1ALDH1A1POLBTSHRKMT2A
SCHEMBL13603918 0.80 NPSR1 (0.44) NPSR1ALDH1A1POLBTSHRKMT2A
SCHEMBL3992095 0.79 TP53 (0.42) NPSR1ALDH1A1POLBTSHRKMT2A
SCHEMBL6044862 0.78 NPSR1 (0.43) NPSR1ALDH1A1POLBTSHRKMT2A
SCHEMBL5247275 0.78 NPSR1 (0.43) NPSR1ALDH1A1POLBTSHRKMT2A
SCHEMBL11669414 0.78 ALDH1A1 (0.41) NPSR1ALDH1A1POLBTSHRKMT2A
SCHEMBL1532229 0.77 RXFP1 (0.48) NPSR1ALDH1A1POLBTSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115884987-A Anti-idiotypic antibodies to anti-GPRC 5D antibodies 詹森生物科技公司 2023-03-31 CN disclosed
EP-1228367-B1 AMINOPHENOXYACETAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF ASUBIO PHARMA CO LTD (JP) 2007-09-26 EP disclosed
US-20060178401-A1 Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof DAIICHI ASUBIO PHARMA CO., LTD. 2006-08-10 US disclosed
US-7067533-B2 Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof DAIICHI ASUBIO PHARMA CO., LTD. (JP) 2006-06-27 US disclosed
US-20030139447-A1 Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof ASUBIO PHARMA CO., LTD. (JP) 2003-07-24 US disclosed
EP-1228367-A2 AMINOPHENOXYACETAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF SUNTORY LIMITED (JP) 2002-08-07 EP disclosed
WO-2001079170-A2 AMINOPHENOXYACETAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF SUNTORY LIMITED (JP) 2001-10-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139447-A1 Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof SCN10A, CAMK2A, CAMK2B NPSR1 2256/4885ALDH1A1 3310/4885POLB 4526/4885
US-20060178401-A1 Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof NR0B1, NR0B2, NR4A1 NPSR1 596/4885ALDH1A1 1322/4885POLB 3328/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.