Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | MMP2 | P08253 | 4/20 | 0.63 |
| ▸ | MMP9 | P14780 | 4/20 | 0.63 |
| ▸ | MMP8 | P22894 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | MMP13 | P45452 | 3/20 | 0.63 |
| ▸ | CASP3 | P42574 | 2/20 | 0.63 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.63 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.63 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.63 |
| ▸ | NPBWR1 | P48145 | 12/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.61 |
| ▸ | RELA | Q04206 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31154234 | 0.81 | NPBWR1 (0.71) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL29026603 | 0.81 | NPBWR1 (0.71) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL20982681 | 0.80 | NPC1 (0.73) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL5566197 | 0.80 | NPC1 (0.78) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL10172964 | 0.78 | NPBWR1 (0.80) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL29026604 | 0.78 | MAPT (0.85) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL5566191 | 0.77 | NPC1 (1.00) | NPC1MAPTRAB9AMMP2MMP9 | |
| Hydrochloric Acid SCHEMBL19739311 | 0.77 | NPBWR1 (0.78) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL31474746 | 0.77 | NPC1 (0.72) | NPC1MAPTRAB9AMMP2MMP9 | |
| SCHEMBL6327841 | 0.77 | NPC1 (0.72) | NPC1MAPTRAB9AMMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256287-B2 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2007-08-14 | — | — | US | disclosed |
| US-7256287-B2 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2007-08-14 | — | — | US | disclosed |
| US-7256287-B2 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2007-08-14 | — | — | US | disclosed |
| EP-1546157-A4 | PHENYL-AZA-BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2007-02-28 | — | — | EP | disclosed |
| EP-1546157-A2 | PHENYL-AZA-BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | Avanir Pharmaceuticals (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20040116466-A1 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS | 2004-06-17 | — | — | US | disclosed |
| WO-2004024897-A2 | PHENYL-AZA-BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2004-03-25 | — | — | WO | disclosed |