Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CFD | P00746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4716848 | 0.95 | LMNA (0.59) | LMNACFDKMT2AEPHX2ALDH1A1 | |
| SCHEMBL4717158 | 0.83 | NLRP3 (0.56) | LMNAKMT2AEPHX2KDRMEN1 | |
| SCHEMBL4716827 | 0.82 | PDGFRB (0.55) | LMNAKMT2AALDH1A1USP2CSF1R | |
| SCHEMBL4717797 | 0.82 | MEN1 (0.57) | LMNAKMT2AALDH1A1SMN1; SMN2KDR | |
| SCHEMBL4717546 | 0.82 | LMNA (0.62) | LMNACFDKMT2AEPHX2ALDH1A1 | |
| SCHEMBL4719226 | 0.81 | KDR (0.58) | LMNAKMT2AEPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3576758 | 0.80 | KDR (0.52) | SMN1; SMN2AURKARPS6KB1AURKBPTPN11 | |
| SCHEMBL4719248 | 0.80 | PTPN11 (0.50) | KMT2AALDH1A1SMN1; SMN2AURKARPS6KB1 | |
| SCHEMBL6101866 | 0.80 | LMNA (0.76) | LMNACFDKMT2AEPHX2ALDH1A1 | |
| SCHEMBL4718064 | 0.79 | SMN1; SMN2 (0.57) | LMNAKMT2ASMN1; SMN2CSF1RMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737462-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005060969-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |