Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.37 |
| ▸ | NCOR1 | O75376 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234145 | 0.82 | DYRK1A (0.44) | PDPK1AKT3MAPTGSK3BJAK2 | |
| SCHEMBL5257150 | 0.80 | PDPK1 (0.43) | PDPK1AKT3HDAC1GSK3BBRAF | |
| SCHEMBL5258491 | 0.77 | HDAC1 (0.43) | HDAC3HDAC2POLBGAAHDAC1 | |
| SCHEMBL5254880 | 0.77 | GSK3B (0.42) | PDPK1AKT3POLBGSK3BBRAF | |
| SCHEMBL5237798 | 0.73 | AKT3 (0.44) | AKT3MAPTGSK3BJAK2BRAF | |
| SCHEMBL2947276 | 0.70 | GSK3B (0.52) | PDPK1AKT3GSK3BBRAF | |
| SCHEMBL4853882 | 0.70 | GSK3B (0.55) | AKT3MAPTGSK3BJAK2 | |
| SCHEMBL2944211 | 0.69 | IDH1 (0.43) | PDPK1AKT3GSK3BBRAFIDH1 | |
| SCHEMBL5256987 | 0.69 | MEN1 (0.42) | HDAC3HDAC2GAAMAPTHDAC1 | |
| SCHEMBL2946867 | 0.69 | GSK3B (0.49) | PDPK1POLBGAAMAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725543-B1 | 4-BENZIMIDAZOL-2-YL-PYRIDAZINE-3-ONE-DERIVATIVES, PRODUCTION AND USE THEREOF IN MEDICAMENTS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-11-28 | — | — | EP | disclosed |
| EP-1725543-A1 | 4-BENZIMIDAZOL-2-YL-PYRIDAZINE-3-ONE-DERIVATIVES, PRODUCTION AND USE THEREOF IN MEDICAMENTS | Sanofi-Aventis Deutschland GmbH (DE) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005085230-A1 | 4-BENZIMIDAZOL-2-YL-PYRIDAZINE-3-ONE-DERIVATIVES, PRODUCTION AND USE THEREOF IN MEDICAMENTS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-09-15 | — | — | WO | disclosed |