Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | GPR39 | O43194 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234145 | 0.91 | DYRK1A (0.44) | AKT3DYRK1ACLK4DYRK1BCLK1 | |
| SCHEMBL4848234 | 0.84 | GSK3B (0.56) | AKT3DYRK1ACLK4DYRK1BCLK1 | |
| SCHEMBL5243212 | 0.83 | GSK3B (0.45) | MAPTGSK3BMEN1KMT2A | |
| SCHEMBL5233270 | 0.81 | EIF2AK2 (0.47) | RAF1BRAFSYKAURKB | |
| SCHEMBL5234548 | 0.79 | MAPT (0.49) | MAPTGSK3B | |
| SCHEMBL5229836 | 0.77 | GSK3B (0.52) | MAPTGSK3BMEN1KMT2A | |
| SCHEMBL5244050 | 0.77 | GSK3B (0.61) | AKT3DYRK1ACLK4DYRK1BCLK1 | |
| SCHEMBL5228636 | 0.77 | GSK3B (0.48) | MAPTGSK3BMEN1KMT2A | |
| SCHEMBL5231030 | 0.76 | GSK3B (0.55) | MAPTGSK3BMEN1KMT2A | |
| SCHEMBL5227844 | 0.75 | GSK3B (0.57) | MAPTGSK3BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611121-B1 | PYRIDAZINONE DERIVATIVES AS CDK2-INHIBITORS | AVENTIS PHARMA SA (FR) | 2007-08-08 | — | — | EP | claimed |
| EP-1581505-B1 | PYRIDAZINONE DERIVATIVES AS GSK-3BETA INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-08-01 | — | — | EP | claimed |