Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 3/20 | 0.34 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254880 | 0.88 | GSK3B (0.42) | PDPK1GSK3BAKT3BRAFMKNK1 | |
| SCHEMBL2947276 | 0.83 | GSK3B (0.52) | PDPK1GSK3BAKT3BRAFMKNK1 | |
| SCHEMBL5234145 | 0.82 | DYRK1A (0.44) | PDPK1GSK3BAKT3BRAFDYRK1A | |
| SCHEMBL5253672 | 0.80 | PDPK1 (0.39) | PDPK1GSK3BAKT3BRAFHDAC1 | |
| SCHEMBL2946867 | 0.79 | GSK3B (0.49) | PDPK1GSK3BKMT2ANPSR1 | |
| SCHEMBL4857179 | 0.72 | GSK3B (0.65) | PDPK1GSK3BCDC7EIF2AK2 | |
| SCHEMBL5235357 | 0.72 | GSK3B (0.66) | GSK3BEIF2AK2DYRK1ACLK4HDAC1 | |
| SCHEMBL4853882 | 0.72 | GSK3B (0.55) | GSK3BAKT3DYRK1ACLK4AURKA | |
| SCHEMBL5237798 | 0.71 | AKT3 (0.44) | GSK3BAKT3BRAFDYRK1ACLK4 | |
| SCHEMBL5230846 | 0.71 | GSK3B (0.76) | GSK3BEIF2AK2DYRK1ACLK4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725543-B1 | 4-BENZIMIDAZOL-2-YL-PYRIDAZINE-3-ONE-DERIVATIVES, PRODUCTION AND USE THEREOF IN MEDICAMENTS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-11-28 | — | — | EP | disclosed |