Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL505546 | 0.82 | ALDH1A1 (0.63) | ALDH1A1HTTSMN1; SMN2MMP13MEN1 | |
| SCHEMBL1095100 | 0.80 | MTNR1A (0.62) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL5073633 | 0.78 | MTNR1A (0.71) | MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL1905739 | 0.78 | MTNR1A (0.46) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL8305017 | 0.75 | TAAR1 (0.58) | — | |
| SCHEMBL3293355 | 0.73 | TAAR1 (0.52) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL1096460 | 0.73 | TAAR1 (0.52) | MTNR1AMTNR1BALDH1A1MEN1KMT2A | |
| SCHEMBL1094980 | 0.72 | TAAR1 (0.48) | MTNR1AMTNR1BALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7746095 | 0.71 | TAAR1 (0.53) | — | |
| SCHEMBL248658 | 0.70 | CHRM2 (0.57) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833473-A2 | 5HT2C RECEPTOR MODULATOR COMPOSITIONS AND METHODS OF USE | Arena Pharmaceuticals, Inc. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006071740-A2 | 5HT2C RECEPTOR MODULATOR COMPOSITIONS AND METHODS OF USE | ARENA PHARMACEUTICALS, INC. (US) | 2006-07-06 | — | — | WO | disclosed |
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |