Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 3/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 5/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3539277 | 0.85 | KDM4E (0.45) | OPRK1MALT1MAPTKDM4EMEN1 | |
| SCHEMBL13009733 | 0.82 | ENPP1 (0.40) | OPRK1DHODHMALT1PRMT5WDR77 | |
| SCHEMBL3545445 | 0.82 | DHODH (0.39) | OPRK1DHODHPRMT5WDR77KDM4E | |
| SCHEMBL3550802 | 0.81 | ACACB (0.39) | OPRK1DHODHACACBPRMT5MAPT | |
| SCHEMBL5252865 | 0.80 | OPRK1 (0.46) | OPRK1DHODHACACBMAPTCYP2C9 | |
| SCHEMBL5252144 | 0.74 | OPRK1 (0.49) | OPRK1ACACBMAPTCYP2C9CYP2C19 | |
| SCHEMBL3549423 | 0.73 | KDM4E (0.46) | OPRK1DHODHMALT1MAPTKDM4E | |
| SCHEMBL3540587 | 0.71 | ENPP1 (0.41) | OPRK1DHODHMALT1PRMT5WDR77 | |
| SCHEMBL13009740 | 0.71 | ENPP1 (0.41) | OPRK1DHODHMALT1PRMT5WDR77 | |
| SCHEMBL27708996 | 0.71 | TRPV1 (0.42) | MAPTCYP2C9CYP2C19KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833806-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006064189-A1 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |