Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5253647 | 0.84 | MEN1 (0.40) | LMNATP53KDM4EALDH1A1MAPK1 | |
| SCHEMBL5115186 | 0.82 | HTT (0.42) | LMNATP53KDM4EALDH1A1HPGD | |
| SCHEMBL5117654 | 0.80 | MAOB (0.48) | LMNATP53KDM4EALDH1A1HPGD | |
| SCHEMBL5120917 | 0.79 | PDE4B (0.41) | LMNATP53KDM4EALDH1A1HPGD | |
| SCHEMBL5127647 | 0.78 | LMNA (0.42) | LMNATP53KDM4EALDH1A1HPGD | |
| SCHEMBL5128066 | 0.78 | MAOB (0.46) | LMNATP53KDM4EALDH1A1HPGD | |
| SCHEMBL5128204 | 0.78 | ALDH1A1 (0.45) | LMNATP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5130113 | 0.77 | ALDH1A1 (0.41) | LMNATP53KDM4EALDH1A1TSHR | |
| SCHEMBL5130127 | 0.77 | TP53 (0.43) | LMNATP53KDM4EALDH1A1HPGD | |
| SCHEMBL14500129 | 0.76 | TP53 (0.44) | LMNATP53KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441734-B1 | DIHYDROXYPYRIMIDINE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE | ANGELETTI P IST RICHERCHE BIO (IT) | 2007-02-28 | — | — | EP | disclosed |