Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237488 | 0.89 | GBA1 (0.60) | GBA1POLBEGFRHCAR3NPC1 | |
| SCHEMBL21841697 | 0.87 | GBA1 (0.47) | GBA1POLBEGFRHCAR3TRPV1 | |
| SCHEMBL1432671 | 0.84 | GBA1 (0.59) | GBA1EGFRHCAR3NPC1ALDH1A1 | |
| SCHEMBL15205756 | 0.81 | GBA1 (0.61) | GBA1EGFRHCAR3NPC1ALDH1A1 | |
| SCHEMBL31217157 | 0.81 | GBA1 (0.56) | GBA1EGFRHCAR3NPC1RAB9A | |
| SCHEMBL2256335 | 0.81 | GBA1 (0.51) | GBA1EGFRHCAR3SSTR2SSTR4 | |
| SCHEMBL22085994 | 0.80 | GBA1 (0.47) | GBA1POLBEGFRHCAR3TRPV1 | |
| SCHEMBL9906944 | 0.80 | POLB (0.51) | POLBEGFRHCAR3TRPV1DGAT1 | |
| SCHEMBL1433090 | 0.79 | GBA1 (0.69) | GBA1HCAR3TRPV1NPC1ALDH1A1 | |
| SCHEMBL10653784 | 0.79 | GBA1 (0.57) | GBA1POLBEGFRHCAR3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230055250-A1 | MAP4K4 INHIBITORS | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2023-02-23 | — | — | US | disclosed |
| WO-2020115481-A1 | MAP4K4 INHIBITORS | IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE (GB) | 2020-06-11 | — | — | WO | disclosed |
| EP-1268431-B1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-08-29 | — | — | EP | disclosed |
| US-20030125358-A1 | Pharmaceutical compositions containing thiazolidinedione derivatives and process for their preparation | SMITHKLINE BEECHAM P.L.C. | 2003-07-03 | — | — | US | disclosed |
| EP-1202991-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING THIAZOLIDINEDIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM PLC (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012628-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING THIAZOLIDINEDIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-02-22 | — | — | WO | disclosed |
| EP-0605524-A1 | ANTIBACTERIAL, ANTIMYCOPLASMAL COMPOUNDS RELATED TO MUPIROCIN | SMITHKLINE BEECHAM PLC (GB) | 1994-07-13 | — | — | EP | disclosed |
| WO-1993006118-A1 | ANTIBACTERIAL, ANTIMYCOPLASMAL COMPOUNDS RELATED TO MUPIROCIN | SMITHKLINE BEECHAM PLC (GB) | 1993-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230055250-A1 | MAP4K4 INHIBITORS | MAP4K4, MAP4K5, MAP4K1 | GBA1 3078/4885POLB 2996/4885EGFR 1053/4885 |
| US-20030125358-A1 | Pharmaceutical compositions containing thiazolidinedione derivatives and process for their preparation | TNNT2, FABP3, TNNI3 | GBA1 1718/4885POLB 3836/4885EGFR 3521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.