SCHEMBL525568

SCHEMBL525568

O=C(O)Cc1ccccc1-c1ccccc1CNC(=O)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.58

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.58
EPHX2 P34913 1/20 0.47
CASP3 P42574 2/20 0.45
FABP7 O15540 2/20 0.43
FABP5 Q01469 2/20 0.43
KCNA5 P22460 2/20 0.43
MDM4 O15151 1/20 0.41
TP53 P04637 1/20 0.41
OPRD1 P41143 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26140029 0.94 KMT2A (0.59) KMT2AEPHX2CASP3FABP7FABP5
SCHEMBL1157557 0.84 EPHX2 (0.55) KMT2AEPHX2CASP3FABP7FABP5
SCHEMBL525564 0.84 KMT2A (0.59) KMT2AEPHX2CASP3FABP7FABP5
SCHEMBL30640436 0.84 KMT2A (0.59) KMT2AEPHX2CASP3FABP7FABP5
SCHEMBL119384 0.84 KMT2A (0.56) KMT2AEPHX2CASP3FABP7FABP5
SCHEMBL30421786 0.84 KMT2A (0.56) KMT2AEPHX2CASP3FABP7FABP5
SCHEMBL18687752 0.83 KMT2A (0.55) KMT2AEPHX2CASP3FABP7FABP5
SCHEMBL30125177 0.83 KMT2A (0.67) KMT2AEPHX2CASP3FABP7FABP5
SCHEMBL29352060 0.83 KMT2A (0.67) KMT2AEPHX2CASP3FABP7FABP5
SCHEMBL29443815 0.83 KMT2A (0.67) KMT2AEPHX2CASP3FABP7FABP5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2598157-B1 CYCLIC PEPTIDES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE PLATELET ADHESION SANOFI SA (FR) 2016-10-12 EP disclosed
US-9073975-B2 Cyclic peptides, their preparation and their use as inhibitors of the platelet adhesion SANOFI (FR) 2015-07-07 US disclosed
US-20140011734-A1 CYCLIC PEPTIDES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE PLATELET ADHESION SANOFI (FR) 2014-01-09 US disclosed
EP-2598157-A1 CYCLIC PEPTIDES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE PLATELET ADHESION SANOFI (FR) 2013-06-05 EP disclosed
WO-2012013709-A1 CYCLIC PEPTIDES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE PLATELET ADHESION SANOFI (FR) 2012-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140011734-A1 CYCLIC PEPTIDES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE PLATELET ADHESION F12, F11, F13B KMT2A 4818/4885EPHX2 2931/4885CASP3 1903/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.