Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.59 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | AXL | P30530 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.59 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.59 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.59 |
| ▸ | PRKX | P51817 | 1/20 | 0.59 |
| ▸ | NEK4 | P51957 | 1/20 | 0.59 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.59 |
| ▸ | STK3 | Q13188 | 1/20 | 0.59 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.59 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5463018 | 0.90 | ABL1 (0.52) | MAPK1DCLK1PDPK1PRKD3MAP4K4 | |
| SCHEMBL5471712 | 0.90 | ABL1 (0.54) | MAPK1DCLK1PDPK1PRKD3MAP4K4 | |
| SCHEMBL5467196 | 0.90 | EGFR (0.53) | MAPK1DCLK1PDPK1PRKD3MAP4K4 | |
| SCHEMBL5469689 | 0.89 | MAPK1 (0.49) | MAPK1DCLK1PDPK1PRKD3MAP4K4 | |
| SCHEMBL5468014 | 0.88 | MAPK1 (0.49) | MAPK1DCLK1PDPK1PRKD3MAP4K4 | |
| SCHEMBL5465074 | 0.88 | RAB9A (0.55) | MAPK1DCLK1PDPK1PRKD3MAP4K4 | |
| SCHEMBL5462901 | 0.88 | DCLK1 (0.48) | MAPK1DCLK1PDPK1PRKD3MAP4K4 | |
| SCHEMBL5465060 | 0.88 | EGFR (0.55) | MAPK1DCLK1PDPK1PRKD3MAP4K4 | |
| SCHEMBL5462327 | 0.87 | FLT3 (0.58) | MAPK1DCLK1PDPK1PRKD3MAP4K4 | |
| SCHEMBL5465063 | 0.87 | ABL1 (0.51) | MAPK1DCLK1PDPK1PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070244133-A1 | Thienopyrimidines and Thiazolopyrimidines for Use in Medicine | ASTRAZENECA AB (SE) | 2007-10-18 | — | — | US | claimed |
| EP-1755610-A2 | THIENOPYRIMIDINES AND THIAZOLOPYRIMIDINES FOR USE IN MEDICINE | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005117890-A2 | THIENOPYRIMIDINES AND THIAZOLOPYRIMIDINES FOR USE IN MEDICINE | ASTRAZENECA AB (SE) | 2005-12-15 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244133-A1 | Thienopyrimidines and Thiazolopyrimidines for Use in Medicine | CXCR4, CXCR1, CXCR3 | MAPK1 1616/4885DCLK1 2628/4885PDPK1 3231/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.