Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | FADS1 | O60427 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.40 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786842 | 0.88 | HTR2A (0.57) | IGF1REGFRFADS1HTR2AHTR2C | |
| SCHEMBL786092 | 0.87 | IGF1R (0.49) | IGF1REGFRPDE4BFADS1VCP | |
| SCHEMBL786744 | 0.85 | FADS1 (0.45) | IGF1REGFRFADS1GSK3AGSK3B | |
| SCHEMBL13107334 | 0.85 | EGFR (0.42) | IGF1REGFRPDE4BFADS1GSK3A | |
| SCHEMBL786140 | 0.84 | IGF1R (0.51) | IGF1REGFRPDE4BHTR2AHTR2C | |
| SCHEMBL14164030 | 0.84 | EGFR (0.42) | IGF1REGFRPDE4BFADS1GSK3A | |
| SCHEMBL785653 | 0.84 | USP1 (0.46) | IGF1REGFRFADS1GSK3AGSK3B | |
| SCHEMBL786233 | 0.84 | FADS1 (0.46) | IGF1REGFRFADS1GSK3AGSK3B | |
| SCHEMBL785480 | 0.84 | USP1 (0.45) | IGF1REGFRFADS1GSK3AGSK3B | |
| SCHEMBL802419 | 0.84 | EGFR (0.43) | IGF1REGFRFADS1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318814-B1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2007-05-30 | — | — | EP | disclosed |