Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GALR2 | O43603 | 1/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | CCR6 | P51684 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677098 | 0.83 | TDP1 (0.49) | ALDH1A1SMN1; SMN2HPGDNPSR1MAPT | |
| SCHEMBL29389855 | 0.82 | TSHR (0.70) | TSHRALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL8927648 | 0.82 | TSHR (0.70) | TSHRALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL1030554 | 0.82 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2LMNAHPGDNPSR1 | |
| SCHEMBL27474529 | 0.81 | ALDH1A1 (0.57) | TSHRALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL1523174 | 0.81 | ALDH1A1 (0.67) | TSHRALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL397015 | 0.80 | ALDH1A1 (0.56) | TSHRALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL4268650 | 0.80 | ALDH1A1 (0.49) | TSHRALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL10900936 | 0.79 | TSHR (0.66) | TSHRALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL15847247 | 0.79 | ALDH1A1 (0.51) | TSHRALDH1A1SMN1; SMN2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100432055-C | Tricyclic protein kinase inhibitors | WYETH CORP (US) | 2008-11-12 | — | — | CN | disclosed |
| EP-1242382-B1 | TRICYCLIC PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-02-07 | — | — | EP | disclosed |
| US-20060247217-A1 | Tricyclic protein kinase inhibitors | BERGER DAN M | 2006-11-02 | — | — | US | disclosed |
| US-7105531-B2 | Tricyclic protein kinase inhibitors | WYETH (US) | 2006-09-12 | — | — | US | disclosed |
| CN-1262541-C | Tricyclic protein kinase inhibitors | WYETH CORP (US) | 2006-07-05 | — | — | CN | disclosed |
| CN-1704404-A | Tricyclic protein kinase inhibitors | WYETH CORP (US) | 2005-12-07 | — | — | CN | disclosed |
| US-20040110762-A1 | Tricyclic protein kinase inhibitors | WYETH | 2004-06-10 | — | — | US | disclosed |
| CN-1437584-A | Tricyclic protein kinase inhibitors | WYETH CORP (US) | 2003-08-20 | — | — | CN | disclosed |
| EP-1242382-A1 | TRICYCLIC PROTEIN KINASE INHIBITORS | Wyeth (US) | 2002-09-25 | — | — | EP | disclosed |
| US-20010051620-A1 | Tricyclic protein kinase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-12-13 | — | — | US | disclosed |
| WO-2001047892-A1 | TRICYCLIC PROTEIN KINASE INHIBITORS | WYETH (US) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110762-A1 | Tricyclic protein kinase inhibitors | CDK1, CDKN1A, CDK2 | TSHR 2485/4885ALDH1A1 3285/4885SMN1; SMN2 4516/4885 |
| US-20060247217-A1 | Tricyclic protein kinase inhibitors | CDK1, CDKN1A, CDK2 | TSHR 2623/4885ALDH1A1 3511/4885SMN1; SMN2 4638/4885 |
| US-20010051620-A1 | Tricyclic protein kinase inhibitors | CDK1, CHEK1, ABL1 | TSHR 1106/4885ALDH1A1 4120/4885SMN1; SMN2 3628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.