Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.57 |
| ▸ | CTSS | P25774 | 6/20 | 0.53 |
| ▸ | CTSV | O60911 | 4/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | UGCG | Q16739 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456064 | 0.93 | CTSK (0.58) | CTSKCTSSCTSVCTSLUSP30 | |
| SCHEMBL5257600 | 0.93 | CTSK (0.58) | CTSKCTSSCTSVCTSLUSP30 | |
| SCHEMBL4457945 | 0.93 | CTSK (0.58) | CTSKCTSSCTSVCTSLUSP30 | |
| SCHEMBL13677171 | 0.93 | CTSK (0.58) | CTSKCTSSCTSVCTSLUSP30 | |
| SCHEMBL5255435 | 0.92 | CTSK (0.57) | CTSKCTSSCTSVCTSLUSP30 | |
| SCHEMBL5253359 | 0.92 | CTSK (0.57) | CTSKCTSSCTSVCTSLUSP30 | |
| SCHEMBL5104885 | 0.92 | CTSS (0.61) | CTSKCTSSCTSVCTSLKLKB1 | |
| SCHEMBL5258559 | 0.91 | CTSK (0.55) | CTSKCTSSCTSVCTSLUSP30 | |
| SCHEMBL5253840 | 0.90 | CTSK (0.57) | CTSKCTSSCTSVCTSLUSP30 | |
| SCHEMBL4452651 | 0.90 | CTSK (0.63) | CTSKCTSSCTSVCTSLCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362052-B1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2007-03-07 | — | — | EP | disclosed |
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |