Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 5/20 | 0.44 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4400689 | 0.86 | MC4R (0.44) | MC4RTRPC5ALDH1A1KDM4E | |
| SCHEMBL4518845 | 0.85 | MC4R (0.61) | MC4RCNR2OPRM1 | |
| SCHEMBL11922706 | 0.77 | MC4R (0.46) | MC4RTRPC5KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL4521447 | 0.74 | KIF11 (0.46) | MC4RKDM4ENPC1CNR2OPRM1 | |
| SCHEMBL4396730 | 0.72 | MC4R (0.61) | MC4RALDH1A1KDM4ECNR2OPRM1 | |
| SCHEMBL5256263 | 0.72 | ITK (0.39) | ALDH1A1NPC1CNR2OPRM1 | |
| Hydrochloric Acid SCHEMBL4399407 | 0.71 | MC4R (0.61) | MC4RALDH1A1KDM4ECNR2OPRM1 | |
| SCHEMBL4398780 | 0.67 | MC4R (0.61) | MC4RCNR2OPRM1 | |
| SCHEMBL4394233 | 0.64 | MC4R (0.79) | MC4RCNR2OPRM1 | |
| Hydrochloric Acid SCHEMBL4403536 | 0.63 | MC4R (0.78) | MC4RCNR2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467974-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS GNRH ANTAGONISTS | SOD CONSEILS RECH APPLIC (FR) | 2007-08-15 | — | — | EP | disclosed |