Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 0.84 |
| ▸ | MAPT | P10636 | 1/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL643338 | 0.86 | HTT (1.00) | ALDH1A1POLBMAPTCYP3A4CYP2C19 | |
| SCHEMBL4521821 | 0.86 | KMT2A (1.00) | ALDH1A1POLBMAPTCYP3A4CYP2C19 | |
| SCHEMBL4513008 | 0.84 | ALDH1A1 (0.72) | ALDH1A1POLBMAPTCYP3A4CYP2C19 | |
| SCHEMBL4513013 | 0.84 | ALDH1A1 (0.72) | ALDH1A1POLBMAPTCYP3A4CYP2C19 | |
| SCHEMBL4526157 | 0.79 | ALDH1A1 (0.77) | ALDH1A1POLBMAPTCYP3A4CYP2C19 | |
| SCHEMBL4526154 | 0.79 | ALDH1A1 (0.77) | ALDH1A1POLBMAPTCYP3A4CYP2C19 | |
| SCHEMBL3534966 | 0.78 | ALDH1A1 (0.76) | ALDH1A1POLBMAPTCYP3A4CYP2C19 | |
| SCHEMBL3534971 | 0.78 | ALDH1A1 (0.76) | ALDH1A1POLBMAPTCYP3A4CYP2C19 | |
| SCHEMBL5982477 | 0.77 | ALDH1A1 (0.74) | ALDH1A1POLBMAPTCYP3A4CYP2C19 | |
| SCHEMBL5982557 | 0.77 | ALDH1A1 (0.74) | ALDH1A1POLBMAPTCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758884-A2 | N-CYCLIC SULFONAMIDO INHIBITORS OF GAMMA SECRETASE | Elan Pharmaceuticals, Inc. (US) | 2007-03-07 | — | — | EP | claimed |
| US-20060035884-A1 | N-cyclic sulfonamido inhibitors of gamma secretase | ELAN PHARMACEUTICALS, INC. (US) | 2006-02-16 | — | — | US | claimed |
| WO-2005113542-A2 | N-CYCLIC SULFONAMIDO INHIBITORS OF GAMMA SECRETASE | ELAN PHARMACEUTICALS, INC. (US) | 2005-12-01 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035884-A1 | N-cyclic sulfonamido inhibitors of gamma secretase | BACE1, BACE2, APH1B | ALDH1A1 2985/4885POLB 3326/4885MAPT 374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.