Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | POLB | P06746 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | BDKRB1 | P46663 | 12/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4526157 | 1.00 | ALDH1A1 (0.77) | ALDH1A1POLBMAPTKMT2ACYP3A4 | |
| SCHEMBL3534971 | 0.84 | ALDH1A1 (0.76) | ALDH1A1POLBMAPTKMT2ACYP3A4 | |
| SCHEMBL3534966 | 0.84 | ALDH1A1 (0.76) | ALDH1A1POLBMAPTKMT2ACYP3A4 | |
| SCHEMBL5984080 | 0.83 | ALDH1A1 (0.74) | ALDH1A1POLBMAPTKMT2ACYP3A4 | |
| SCHEMBL5982557 | 0.83 | ALDH1A1 (0.74) | ALDH1A1POLBMAPTKMT2ACYP3A4 | |
| SCHEMBL5982477 | 0.83 | ALDH1A1 (0.74) | ALDH1A1POLBMAPTKMT2ACYP3A4 | |
| SCHEMBL5256359 | 0.79 | ALDH1A1 (1.00) | ALDH1A1POLBMAPTKMT2ACYP3A4 | |
| SCHEMBL4339955 | 0.76 | ALDH1A1 (0.64) | ALDH1A1POLBMAPTKMT2ACYP3A4 | |
| SCHEMBL4339959 | 0.76 | ALDH1A1 (0.64) | ALDH1A1POLBMAPTKMT2ACYP3A4 | |
| SCHEMBL4521821 | 0.76 | KMT2A (1.00) | ALDH1A1POLBMAPTKMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054460-A1 | Piperazine derivatives and methods of use | CHEN JIAN J | 2009-02-26 | — | — | US | disclosed |
| US-7393852-B2 | Piperazine derivatives and methods of use | AMGEN INC. (US) | 2008-07-01 | — | — | US | disclosed |
| EP-1656355-B1 | PIPERAZINE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1878728-A2 | Derivatives of piperazine and higher homologues thereof for the treatment of inflammation-related disorders | Amgen Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| US-20050014749-A1 | analgesics; antiinflammatory agents; antiarthritic agents;Alzheimer's disease; cirrhosis; antiallergens; antihistamines ; anticancer agents; vision defects | AMGEN INC. | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054460-A1 | Piperazine derivatives and methods of use | PTGES, PTGES2, PTGIS | ALDH1A1 184/4885POLB 1384/4885MAPT 3351/4885 |
| US-20050014749-A1 | analgesics; antiinflammatory agents; antiarthritic agents;Alzheimer's disease; cirrhosis; antiallergens; antihistamines ; anticancer agents; vision defects | ACHE, TNF, BCHE | ALDH1A1 81/4885POLB 3504/4885MAPT 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.