Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.34 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4840394 | 0.91 | SYK (0.35) | NPC1RAB9AKMT2AMAP3K8HPSE | |
| SCHEMBL4834899 | 0.78 | MMP2 (0.43) | NPC1RAB9AKMT2AHPSESMN1; SMN2 | |
| SCHEMBL4837685 | 0.78 | TAAR1 (0.47) | — | |
| SCHEMBL5258759 | 0.78 | NPC1 (0.38) | NPC1RAB9AKMT2AHPSEAURKA | |
| SCHEMBL5259468 | 0.78 | NPC1 (0.34) | NPC1RAB9AKMT2AHPSEAURKA | |
| SCHEMBL5261764 | 0.77 | HPSE (0.39) | NPC1RAB9AKMT2AHPSETP53 | |
| SCHEMBL5261107 | 0.77 | NPC1 (0.62) | NPC1RAB9AKMT2AMEN1GFER | |
| SCHEMBL5257452 | 0.76 | NPC1 (0.34) | NPC1RAB9AKMT2AHPSEAURKA | |
| SCHEMBL5259906 | 0.76 | LMNA (0.43) | NPC1RAB9AKMT2AHPSEKDR | |
| SCHEMBL4844738 | 0.76 | HPSE (0.41) | NPC1RAB9AHPSEABL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539759-B1 | NOVEL IMIDAZOPYRIDINES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-08-15 | — | — | EP | claimed |