Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 1/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.53 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.53 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.53 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.53 |
| ▸ | SLC18A3 | Q16572 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16599590 | 0.82 | HRH3 (0.58) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL518740 | 0.71 | PRKAA2 (0.77) | PRKAB2PRKAG1PRKAA2KCNH2PRKAA1 | |
| SCHEMBL518735 | 0.71 | PRKAA2 (0.70) | PRKAB2PRKAG1PRKAA2KCNH2PRKAA1 | |
| SCHEMBL30516673 | 0.71 | SLC18A3 (0.74) | SLC18A3TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL1035332 | 0.70 | PRKAA2 (0.69) | PRKAB2PRKAG1PRKAA2KCNH2PRKAA1 | |
| SCHEMBL517986 | 0.69 | PRKAB2 (1.00) | PRKAB2PRKAG1PRKAA2KCNH2PRKAA1 | |
| SCHEMBL518414 | 0.69 | PRKAB2 (0.83) | PRKAB2PRKAG1PRKAA2KCNH2PRKAA1 | |
| SCHEMBL10284366 | 0.68 | PRKAB2 (0.86) | PRKAB2PRKAG1PRKAA2KCNH2PRKAA1 | |
| SCHEMBL518529 | 0.68 | PRKAA2 (0.90) | PRKAB2PRKAG1PRKAA2KCNH2PRKAA1 | |
| SCHEMBL518679 | 0.68 | PRKAB2 (0.87) | PRKAB2PRKAG1PRKAA2KCNH2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598483-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2013-06-05 | — | — | EP | claimed |
| WO-2012016217-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | claimed |