Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 14/20 | 0.44 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.40 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.40 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466557 | 0.86 | TTK (0.55) | TTKALKJAK2SRCTNK2 | |
| SCHEMBL16003359 | 0.79 | MAPT (0.48) | PLK1PLK3PLK2ALKNEK6 | |
| SCHEMBL3504890 | 0.76 | EGFR (0.48) | PLK1PLK3PLK2ALKNEK6 | |
| SCHEMBL12473971 | 0.75 | ALK (0.53) | TTKPLK1ALKTNK2PTK2 | |
| SCHEMBL1559108 | 0.75 | TTK (0.85) | TTKPLK1PLK3PLK2CSNK2A2 | |
| SCHEMBL409329 | 0.74 | PLK1 (0.45) | PLK1PLK3PLK2ALKCSNK2A2 | |
| SCHEMBL24620200 | 0.72 | PLK1 (0.43) | PLK1PLK3PLK2ALKSRC | |
| SCHEMBL16003521 | 0.72 | SIRT6 (0.45) | PLK1 | |
| SCHEMBL16250622 | 0.72 | PLK1 (0.47) | PLK1PLK3PLK2ALKNEK6 | |
| SCHEMBL12500027 | 0.72 | TTK (0.51) | TTKPLK1ALKROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | claimed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | claimed |
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |