Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 10/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.51 |
| ▸ | INSR | P06213 | 2/20 | 0.50 |
| ▸ | NPM1 | P06748 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.48 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12473971 | 0.88 | ALK (0.53) | TTKALKTNK2INSRPTK2 | |
| SCHEMBL525859 | 0.86 | TTK (0.44) | TTKALKJAK2SRCTNK2 | |
| SCHEMBL12500027 | 0.84 | TTK (0.51) | TTKALKINSR | |
| SCHEMBL12466371 | 0.83 | TTK (0.54) | TTKALKTNK2INSRNPM1 | |
| SCHEMBL21566486 | 0.79 | SIRT6 (0.59) | HTR6SIRT6BRD4 | |
| SCHEMBL20374427 | 0.78 | HTR6 (0.56) | TTKALKJAK2SRCTNK2 | |
| SCHEMBL12718983 | 0.76 | SIRT6 (0.56) | ALKTNK2INSRNPM1HTR6 | |
| SCHEMBL17837354 | 0.76 | IRAK4 (0.55) | ALKHTR6DYRK1ASIRT6 | |
| SCHEMBL30605716 | 0.75 | SIRT6 (0.55) | ALKINSRNPM1HTR6CCNT1 | |
| SCHEMBL2490291 | 0.75 | TNK2 (0.51) | ALKTNK2INSRNPM1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668190-A1 | TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2013-12-04 | — | — | EP | claimed |
| WO-2012101032-A1 | TRICYCLIC PYRROLO DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-08-02 | — | — | WO | claimed |