Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3797749 | 1.00 | NPC1 (0.49) | NPC1RAB9ARECQLSMN1; SMN2AAK1 | |
| SCHEMBL3670192 | 1.00 | NPC1 (0.49) | NPC1RAB9ARECQLSMN1; SMN2AAK1 | |
| SCHEMBL5505022 | 0.84 | EPHX2 (0.37) | NPC1RAB9ARECQLSMN1; SMN2AAK1 | |
| SCHEMBL1141998 | 0.83 | NPC1 (0.51) | NPC1RAB9ARECQLSMN1; SMN2AAK1 | |
| SCHEMBL3953935 | 0.80 | DHODH (0.38) | NPC1RAB9AAAK1CTSSCTSK | |
| SCHEMBL3650222 | 0.80 | RAB9A (0.43) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL1208679 | 0.79 | NPC1 (0.48) | NPC1RAB9ARECQLSMN1; SMN2AAK1 | |
| SCHEMBL5503662 | 0.79 | ALDH1A1 (0.46) | NPC1RAB9ARECQLSMN1; SMN2MEN1 | |
| SCHEMBL1141266 | 0.78 | NPC1 (0.47) | NPC1RAB9ARECQLSMN1; SMN2AAK1 | |
| SCHEMBL1433131 | 0.77 | NPC1 (0.43) | NPC1RAB9ARECQLSMN1; SMN2AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781662-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | Pfizer, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018725-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2006-02-23 | — | — | WO | disclosed |