Guanine

Guanine

SCHEMBL5259

Nc1nc2[nH]cnc2c(=O)[nH]1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.61
KDM4E B2RXH2 2/20 0.61
HSD17B10 Q99714 2/20 0.61
LMNA P02545 1/20 0.61
GLA P06280 1/20 0.61
PMP22 Q01453 1/20 0.61
PNP P00491 3/20 0.53
DYRK1A Q13627 1/20 0.49
MAPT P10636 2/20 0.44
TP53 P04637 2/20 0.43
HBB P68871 2/20 0.43
THRB P10828 2/20 0.43
MITF O75030 1/20 0.43
ALOX15 P16050 1/20 0.43
HIF1A Q16665 1/20 0.43
AKR1B1 P15121 1/20 0.41
HPGD P15428 2/20 0.41
XDH P47989 2/20 0.41
USP2 O75604 1/20 0.41
ADORA3 P0DMS8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL4658042 1.00 ALDH1A1 (0.61) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL28217362 0.98 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL21611717 0.98 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL27759765 0.98 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL2895087 0.98 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL28373862 0.98 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL9512016 0.98 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL4063556 0.98 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL865492 0.98 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL28135149 0.98 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 263727 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
US-20260146277-A1 APPLICATION FOR PEPTIDE NUCLEIC ACID (PNA) BLOCKER BECTON, DICKINSON AND COMPANY (US) 2026-05-28 US claimed
US-20260146249-A1 ANTISENSE OLIGONUCLEOTIDES FOR TREATING A DISEASE OR CONDITION ASSOCIATED WITH AN ABNORMAL PROCESSING OF APP VICO THERAPEUTICS B.V. (NL) 2026-05-28 US claimed
US-20260144796-A1 Compounds and Methods for Improving Health Acurx Pharmaceuticals, Inc. (US) 2026-05-28 US claimed
EP-4747387-A1 COAGULATION FACTOR XI-MODULATING COMPOSITIONS AND METHODS OF USE THEREOF Adarx Pharmaceuticals, Inc. (US) 2026-05-27 EP claimed
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
EP-4223352-B1 DRUG-COATED BALLOON CATHETERS FOR BODY LUMENS UROTRONIC INC (US) 2026-05-27 EP claimed
EP-4746696-A1 METHOD OF DETECTING MAIZE PLANTS WITH ALTERED ALEURONE ANTHOCYANIN CONTENT AND ASSOCIATED MARKER ALLELES AND HAPLOTYPES Agreliant Genetics, LLC (US) 2026-05-27 EP claimed
EP-4291664-B1 SITE-SPECIFIC GENOME MODIFICATION TECHNOLOGY UNIV NORTH CAROLINA STATE (US) 2026-05-27 EP claimed
US-12636301-B2 5′-modified carbocyclic ribonucleotide derivatives and methods of use SANEGENE BIO USA INC. (US) 2026-05-26 US claimed
US-4105656-A PROCESS FOR PREPARING 3-N-MONOSUBSTITUTED AMINO-4-SUBSTITUTED-5-PYRAZOLONES FUJI PHOTO FILM CO., LTD. (JP) 1978-08-08 US claimed
US-4101648-A ADENINE AND GUANINE IN AMORPHOUS SILICIC ACID DR. EDUARD FRESENIUS CHEMISCH-PHARMAZEUTISCHE INDUSTRIE KG (DE) 1978-07-18 US claimed
US-4086137-A BACILLUS KYOWA HAKKO KOGYO CO., LTD. (JA) 1978-04-25 US claimed
US-4082911-A PROCESS FOR THE PREPARATION OF NUCLEOSIDES SCHERING AKTIENGESELLSCHAFT (DT) 1978-04-04 US claimed
US-4061591-A Selective adsorbent for use in affinity chromatography PIERCE CHEMICAL COMPANY (US) 1977-12-06 US claimed
US-4056673-A VIRICIDE, ANTINEOPLASTIC HOFFMANN-LA ROCHE INC. (US) 1977-11-01 US claimed
US-4042733-A Forming solid, adhesive-free composite of membrane filters and cellulosic cardboard BOEHRINGER INGELHEIM GMBH (DT) 1977-08-16 US claimed
US-3982948-A Process for preparing silver halide emulsion containing a rhodium salt and a decomposition product of nucleic acid KONISHIROKU PHOTO CO. LTD. (JA) 1976-09-28 US claimed
US-3939089-A PEROXYSULFATE TOKAI DENKA KOGYO KABUSHIKI KAISHA (JA) 1976-02-17 US claimed
US-3937809-A ADDITION COMPOUND OF A NUCLEOTIDE AND AN AMINO ACID AND THE USE THEREOF IN PROTECTION AGAINST ACTINIC RADIATION KOLMAR LABORATORIES, INC. (US) 1976-02-10 US claimed