Guanine

Guanine

SCHEMBL9512016

Nc1nc2[nH]cnc2c(=O)[nH]1.[Na].[Na]

nearest known ligand 0.59

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.59
KDM4E B2RXH2 2/20 0.59
HSD17B10 Q99714 2/20 0.59
LMNA P02545 1/20 0.59
GLA P06280 1/20 0.59
PMP22 Q01453 1/20 0.59
PNP P00491 3/20 0.51
DYRK1A Q13627 1/20 0.47
MAPT P10636 2/20 0.43
TP53 P04637 2/20 0.42
HBB P68871 2/20 0.42
THRB P10828 2/20 0.42
MITF O75030 1/20 0.42
ALOX15 P16050 1/20 0.42
HIF1A Q16665 1/20 0.42
AKR1B1 P15121 1/20 0.41
XDH P47989 2/20 0.40
HPGD P15428 2/20 0.40
USP2 O75604 1/20 0.40
ADORA3 P0DMS8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL5259 0.98 ALDH1A1 (0.61) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL4658042 0.98 ALDH1A1 (0.61) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL28217362 0.96 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL21611717 0.96 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL27400536 0.96 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL28373862 0.96 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL2895087 0.96 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL4063556 0.96 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL865492 0.96 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA
Guanine SCHEMBL27352652 0.96 ALDH1A1 (0.59) ALDH1A1KDM4EHSD17B10LMNAGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0304004-B1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1993-11-03 EP claimed
CN-110869005-A Dispensing capsule containing a solubilizer for a pharmaceutically active ingredient or dietary supplement 雅典娜股份公司 2020-03-06 CN disclosed
CN-105585601-B Anti-aging skin external composition and preparation method thereof 株式会社林原 2018-11-13 CN disclosed
CN-105585601-A Anti-aging skin external composition and preparation method thereof HAYASHIBARA CO 2016-05-18 CN disclosed
CN-104918603-A Anti-aging skin external composition and preparation method thereof HAYASHIBARA CO 2015-09-16 CN disclosed
EP-0304004-B1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1993-11-03 EP disclosed
EP-0304004-A1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1989-02-22 EP disclosed
EP-0304004-A1 Process for the production of sodium purines BOEHRINGER INGELHEIM KG (DE) 1989-02-22 EP disclosed