Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CD69 | Q07108 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5259025 | 1.00 | PTGDR (0.44) | PTGDRPTGDR2KDM4EKMT2AALDH1A1 | |
| SCHEMBL2061886 | 0.83 | RAB9A (0.41) | KDM4EKMT2AALDH1A1HTTNPC1 | |
| SCHEMBL11211677 | 0.82 | ALDH1A1 (0.42) | KDM4EKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL430053 | 0.81 | KDM4E (0.40) | KDM4E | |
| SCHEMBL430052 | 0.81 | KDM4E (0.40) | KDM4E | |
| SCHEMBL7857063 | 0.79 | PTGDR2 (0.56) | PTGDRPTGDR2KDM4EKMT2AALDH1A1 | |
| SCHEMBL6742518 | 0.78 | PTGDR2 (0.48) | PTGDRPTGDR2KDM4EKMT2AALDH1A1 | |
| Bicarbonate SCHEMBL28219371 | 0.77 | ALDH1A1 (0.51) | KDM4EKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL14374948 | 0.77 | POLB (0.37) | KDM4EKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL5261603 | 0.77 | KMT2A (0.41) | PTGDRPTGDR2KDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786822-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024517-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |