Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.49 |
| ▸ | USP1 | O94782 | 3/20 | 0.48 |
| ▸ | WDR48 | Q8TAF3 | 3/20 | 0.48 |
| ▸ | FADS1 | O60427 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 2/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786427 | 0.90 | USP1 (0.61) | MEN1KMT2AMAPTLMNATP53 | |
| SCHEMBL785470 | 0.89 | FADS1 (0.53) | MEN1KMT2AMAPTMAPK1LMNA | |
| SCHEMBL786256 | 0.82 | USP1 (0.64) | MEN1KMT2AMAPTLMNATP53 | |
| SCHEMBL785772 | 0.82 | USP1 (0.61) | MEN1KMT2AMAPTLMNATP53 | |
| SCHEMBL1083832 | 0.80 | USP1 (0.47) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL10268959 | 0.80 | USP1 (0.47) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL801914 | 0.79 | FADS1 (0.49) | MEN1KMT2AMAPTPOLBMAPK1 | |
| SCHEMBL786042 | 0.79 | CYP1A2 (0.58) | MEN1KMT2AMAPTLMNATP53 | |
| SCHEMBL785641 | 0.79 | USP1 (0.56) | MEN1KMT2AMAPTLMNATP53 | |
| SCHEMBL786391 | 0.79 | CYP1A2 (0.57) | MEN1KMT2AMAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318814-B1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2007-05-30 | — | — | EP | disclosed |