Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4900015 | 0.81 | MECP2 (0.50) | KMT2ANPC1RAB9AL3MBTL1ALOX15 | |
| SCHEMBL5259981 | 0.80 | KMT2A (0.47) | KMT2ANPC1RAB9AL3MBTL1ALOX15 | |
| SCHEMBL4899470 | 0.76 | GRM5 (0.50) | KMT2ANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4900021 | 0.76 | KMT2A (0.44) | KMT2ANPC1RAB9AL3MBTL1ALOX15 | |
| SCHEMBL4897041 | 0.73 | KMT2A (0.47) | KMT2ANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL4895056 | 0.73 | GRM5 (0.56) | KMT2AMEN1MAPK10GFERGRM5 | |
| SCHEMBL2485883 | 0.73 | KMT2A (0.73) | KMT2ANPC1RAB9AL3MBTL1ALOX15 | |
| SCHEMBL4902852 | 0.73 | GRM5 (0.53) | KMT2ANPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4904931 | 0.71 | GRM5 (0.50) | KMT2ANPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL221242 | 0.71 | KMT2A (0.76) | KMT2ANPC1RAB9AL3MBTL1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737852-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | Icagen, Inc. (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100349-A2 | POLYCYCLIC PYRIDINES AS POTASSIUM ION CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-10-27 | — | — | WO | disclosed |