Guanine

Guanine

SCHEMBL5260

Nc1nc2nc[nH]c2c(=O)[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PNP P00491 2/20 1.00
ALDH1A1 P00352 2/20 0.61
KDM4E B2RXH2 1/20 0.61
MEN1 O00255 1/20 0.61
MAPT P10636 1/20 0.61
THRB P10828 1/20 0.61
HPGD P15428 1/20 0.61
KMT2A Q03164 1/20 0.61
HSD17B10 Q99714 1/20 0.61
GRIA1 P42261 1/20 0.53
GRIA2 P42262 1/20 0.53
GRIA3 P42263 1/20 0.53
GRIA4 P48058 1/20 0.53
GDA Q9Y2T3 2/20 0.51
DPP4 P27487 1/20 0.50
PDPK1 O15530 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL1264884 1.00 PNP (1.00) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL986801 1.00 PNP (1.00) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL29370543 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL9511597 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL29822618 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL2895089 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL30967430 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL22533907 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL21611718 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL19436607 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 263340 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
US-20260146277-A1 APPLICATION FOR PEPTIDE NUCLEIC ACID (PNA) BLOCKER BECTON, DICKINSON AND COMPANY (US) 2026-05-28 US claimed
US-20260146249-A1 ANTISENSE OLIGONUCLEOTIDES FOR TREATING A DISEASE OR CONDITION ASSOCIATED WITH AN ABNORMAL PROCESSING OF APP VICO THERAPEUTICS B.V. (NL) 2026-05-28 US claimed
US-20260144796-A1 Compounds and Methods for Improving Health Acurx Pharmaceuticals, Inc. (US) 2026-05-28 US claimed
EP-4747387-A1 COAGULATION FACTOR XI-MODULATING COMPOSITIONS AND METHODS OF USE THEREOF Adarx Pharmaceuticals, Inc. (US) 2026-05-27 EP claimed
EP-4746696-A1 METHOD OF DETECTING MAIZE PLANTS WITH ALTERED ALEURONE ANTHOCYANIN CONTENT AND ASSOCIATED MARKER ALLELES AND HAPLOTYPES Agreliant Genetics, LLC (US) 2026-05-27 EP claimed
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
EP-4223352-B1 DRUG-COATED BALLOON CATHETERS FOR BODY LUMENS UROTRONIC INC (US) 2026-05-27 EP claimed
EP-4291664-B1 SITE-SPECIFIC GENOME MODIFICATION TECHNOLOGY UNIV NORTH CAROLINA STATE (US) 2026-05-27 EP claimed
US-12637489-B2 Silicon containing modified nucleotide analogs Singular Genomics Systems, Inc. (US) 2026-05-26 US claimed
US-4101648-A ADENINE AND GUANINE IN AMORPHOUS SILICIC ACID DR. EDUARD FRESENIUS CHEMISCH-PHARMAZEUTISCHE INDUSTRIE KG (DE) 1978-07-18 US claimed
US-4086137-A BACILLUS KYOWA HAKKO KOGYO CO., LTD. (JA) 1978-04-25 US claimed
US-4082911-A PROCESS FOR THE PREPARATION OF NUCLEOSIDES SCHERING AKTIENGESELLSCHAFT (DT) 1978-04-04 US claimed
US-4061591-A Selective adsorbent for use in affinity chromatography PIERCE CHEMICAL COMPANY (US) 1977-12-06 US claimed
US-4060616-A VIRICIDE BURROUGHS WELLCOME CO. (US) 1977-11-29 US claimed
US-4056673-A VIRICIDE, ANTINEOPLASTIC HOFFMANN-LA ROCHE INC. (US) 1977-11-01 US claimed
US-4042733-A Forming solid, adhesive-free composite of membrane filters and cellulosic cardboard BOEHRINGER INGELHEIM GMBH (DT) 1977-08-16 US claimed
US-3982948-A Process for preparing silver halide emulsion containing a rhodium salt and a decomposition product of nucleic acid KONISHIROKU PHOTO CO. LTD. (JA) 1976-09-28 US claimed
US-3939089-A PEROXYSULFATE TOKAI DENKA KOGYO KABUSHIKI KAISHA (JA) 1976-02-17 US claimed
US-3937809-A ADDITION COMPOUND OF A NUCLEOTIDE AND AN AMINO ACID AND THE USE THEREOF IN PROTECTION AGAINST ACTINIC RADIATION KOLMAR LABORATORIES, INC. (US) 1976-02-10 US claimed