Sugi Predict

Sugi Predict / Compounds / Guanine

Guanine

Guanine

SCHEMBL986801

Nc1nc2nc[nH]c2c(=O)[nH]1.Nc1nc2nc[nH]c2c(=O)[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PNP P00491 2/20 1.00
▸ ALDH1A1 P00352 2/20 0.61
▸ KDM4E B2RXH2 1/20 0.61
▸ MEN1 O00255 1/20 0.61
▸ MAPT P10636 1/20 0.61
▸ THRB P10828 1/20 0.61
▸ HPGD P15428 1/20 0.61
▸ KMT2A Q03164 1/20 0.61
▸ HSD17B10 Q99714 1/20 0.61
▸ GRIA1 P42261 1/20 0.53
▸ GRIA2 P42262 1/20 0.53
▸ GRIA3 P42263 1/20 0.53
▸ GRIA4 P48058 1/20 0.53
▸ GDA Q9Y2T3 2/20 0.51
▸ DPP4 P27487 1/20 0.50
▸ PDPK1 O15530 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL1264884 1.00 PNP (1.00) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL5260 1.00 PNP (1.00) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL29370543 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL9511597 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL29822618 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL2895089 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL30967430 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL22533907 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL21611718 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT
Guanine SCHEMBL19436607 0.98 PNP (0.96) PNPALDH1A1KDM4EMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 231 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4602164-A2 SMALL INTERFERING RNA TARGETING C3 AND USES THEREOF Sanegene Bio USA Inc. (US) 2025-08-20 — — EP claimed
WO-2024081954-A2 SMALL INTERFERING RNA TARGETING C3 AND USES THEREOF SANEGENE BIO USA INC. (US) 2024-04-18 — — WO claimed
US-20240055073-A1 SAMPLE CONTAMINATION DETECTION OF CONTAMINATED FRAGMENTS WITH CPG-SNP CONTAMINATION MARKERS GRAIL, LLC 2024-02-15 — — US claimed
WO-2024025831-A1 SAMPLE CONTAMINATION DETECTION OF CONTAMINATED FRAGMENTS WITH CPG-SNP CONTAMINATION MARKERS GRAIL, LLC (US) 2024-02-01 — — WO claimed
US-11827880-B2 Therapeutic editing SHAPE THERAPEUTICS INC. (US) 2023-11-28 — — US claimed
WO-2023092102-A1 DOUBLE STRANDED RNA TARGETING ANGIOPOIETIN-LIKE 3 (ANGPTL-3) AND METHODS OF USE THEREOF SANEGENE BIO USA INC. (US) 2023-05-25 — — WO claimed
US-20230044119-A1 Therapeutic Editing SHAPE THERAPEUTICS INC. 2023-02-09 — — US claimed
CN-115038789-A Therapeutic editing 塑造治疗公司 2022-09-09 — — CN claimed
WO-2021113270-A1 THERAPEUTIC EDITING SHAPE THERAPEUTICS INC. (US) 2021-06-10 — — WO claimed
WO-2016040602-A1 REDUCED REPRESENTATION BISULFITE SEQUENCING USING URACIL N-GLYCOSYLASE (UNG) AND ENDONUCLEASE IV EPICENTRE TECHNOLOGIES CORPORATION (US) 2016-03-17 — — WO claimed
US-6808884-B2 INTERCALATION COMPOUND FOR USE IN THE DIAGNOSIS AND DETECTION OF GENETIC DISORDERS CALIFORNIA INSTITUTE OF TECHNOLOGY 2004-10-26 — — US claimed
EP-1425419-A2 ELECTROCHEMICAL SENSOR USING INTERCALATIVE, REDOX-ACTIVE MOIETIES California Institute Of Technology (US) 2004-06-09 — — EP claimed
US-20040063126-A1 Electrochemical sensor using intercalative, redox-active moieties NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-04-01 — — US claimed
WO-2002057492-A9 METHODS AND COMPOSITIONS FOR DETECTING POLYNUCLEOTIDE DUPLEX DAMAGE CALIFORNIA INST OF TECHN (US) 2003-12-18 — — WO claimed
US-6649350-B2 Detecting nucleotide sequence mutations in sample; obtain nucleotide sequence sample, form film, immerse the nucleic acid film in solution, measure electrical current and detect nucleotide sequence adjustment CALIFORNIA INSTITUTE OF TECHNOLOGY 2003-11-18 — — US claimed
EP-1349962-A1 METHODS AND COMPOSITIONS FOR DETECTING POLYNUCLEOTIDE DUPLEX DAMAGE CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2003-10-08 — — EP claimed
WO-2003023365-A2 ELECTROCHEMICAL SENSOR USING INTERCALATIVE, REDOX-ACTIVE MOIETIES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2003-03-20 — — WO claimed
US-20020155470-A1 Methods and compositions for detecting polynucleotide duplex damage and errors CALIFORNIA INSTITUTE OF TECHNOLOGY 2002-10-24 — — US claimed
US-20020146716-A1 Electrochemical sensor using intercalative, redox-active moieties CALIFORNIA INSTITUTE OF TECHNOLOGY 2002-10-10 — — US claimed
WO-2002057492-A1 METHODS AND COMPOSITIONS FOR DETECTING POLYNUCLEOTIDE DUPLEX DAMAGE CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2002-07-25 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020155470-A1 Methods and compositions for detecting polynucleotide duplex damage and errors POLRMT, POLN, POLM PNP 116/4885ALDH1A1 3798/4885KDM4E 4858/4885
US-20230044119-A1 Therapeutic Editing DCLRE1B, NSUN3, MTREX PNP 134/4885ALDH1A1 1897/4885KDM4E 2892/4885
US-11827880-B2 Therapeutic editing DCLRE1B, NSUN3, MTREX PNP 134/4885ALDH1A1 1897/4885KDM4E 2892/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.