Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Guanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.59 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.59 |
| ▸ | GRIA1 known ✓ | P42261 | 1/20 | 0.51 |
| ▸ | GRIA2 known ✓ | P42262 | 1/20 | 0.51 |
| ▸ | GRIA3 known ✓ | P42263 | 1/20 | 0.51 |
| ▸ | GRIA4 known ✓ | P48058 | 1/20 | 0.51 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.49 |
| ▸ | PNP | P00491 | 2/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL1264884 | 0.98 | PNP (1.00) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL5260 | 0.98 | PNP (1.00) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL986801 | 0.98 | PNP (1.00) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL29562392 | 0.96 | PNP (0.96) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL22533907 | 0.96 | PNP (0.96) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL9511597 | 0.96 | PNP (0.96) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL30967430 | 0.96 | PNP (0.96) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL21611718 | 0.96 | PNP (0.96) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL28373863 | 0.96 | PNP (0.96) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL19436607 | 0.96 | PNP (0.96) | PNPALDH1A1KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112920247-B | Method for modifying DNA by using glycosidase and oxyamine compound | 南京大学 | 2022-12-27 | — | — | CN | claimed |
| US-20250020623-A1 | Water Monitoring with Solid State Nanopores | Goeppert, LLC | 2025-01-16 | — | — | US | disclosed |
| WO-2024040576-A1 | OBJECT DETECTION METHOD, DEEP LEARNING TRAINING METHOD, ELECTRONIC DEVICE, AND MEDIUM | 京东方科技集团股份有限公司 | 2024-02-29 | — | — | WO | disclosed |
| CN-110418847-A | By stepwise sequencing of unlabeled reversible terminators or natural nucleotides | COMPLETE GENOMICS INC | 2019-11-05 | — | — | CN | disclosed |
| CN-110382709-A | Adapter capable of conversion | 维尔道应用技术大学 | 2019-10-25 | — | — | CN | disclosed |
| CN-109790535-A | Prevent the method and composition of concatemerization during template switch | 新英格兰生物实验室公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-108885648-A | System and method for analyzing nucleic acids | 托马生物科学公司 | 2018-11-23 | — | — | CN | disclosed |
| CN-108486236-A | Method and system for determining haplotype He determining phase haplotype | 伊鲁米纳剑桥有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-108192948-A | A kind of method using alpha hemolysin nano-pore detection DNA glycosylase activity | 临沂大学 | 2018-06-22 | — | — | CN | disclosed |
| CN-104508144-B | Methods and systems for determining haplotypes and phasing haplotypes | 伊鲁米纳剑桥有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-104458988-A | Method for testing group of biomarkers | SHANDONG TECHNICAL CT INSPECTION & QUARANTINE | 2015-03-25 | — | — | CN | disclosed |
| CN-102459632-A | Amplification of complex nucleic acids | QIAGEN GMBH | 2012-05-16 | — | — | CN | disclosed |
| CN-102317473-A | Classification of nucleic acid templates | PACIFIC BIOSCIENCES CALIFORNIA | 2012-01-11 | — | — | CN | disclosed |
| EP-2158474-A1 | GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR | SRU Biosystems, Inc. (US) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008156560-A1 | GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR | SRU BIOSYSTEMS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| EP-1913366-A2 | GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR | SRU Biosystems, Inc. (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007019024-A2 | GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR | SRU BIOSYSTEMS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |
| CN-1543350-A | Immunogenic conjugates of carbohydrate haptens and aggregated protein carriers | — | 2004-11-03 | — | — | CN | disclosed |
| EP-0216459-B1 | 9-SUBSTITUTED GUANINE MONOHYDRATES | BEECHAM GROUP PLC (GB) | 1990-05-16 | — | — | EP | disclosed |
| EP-0216459-A1 | 9-Substituted guanine monohydrates | BEECHAM GROUP PLC (GB) | 1987-04-01 | — | — | EP | disclosed |