Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5263135 | 0.89 | GPR119 (0.43) | GPR119SMN1; SMN2 | |
| SCHEMBL389452 | 0.89 | GPR119 (0.71) | GPR119 | |
| SCHEMBL27631836 | 0.86 | GPR119 (0.58) | GPR119LMNA | |
| SCHEMBL5259999 | 0.84 | GPR119 (0.69) | GPR119LMNA | |
| SCHEMBL1673930 | 0.84 | GPR119 (0.51) | GPR119SMN1; SMN2RPS6KB1 | |
| SCHEMBL5262539 | 0.83 | GPR119 (0.79) | GPR119 | |
| SCHEMBL5264179 | 0.83 | GPR119 (0.54) | GPR119SMN1; SMN2LMNA | |
| SCHEMBL4706413 | 0.83 | GPR119 (0.37) | GPR119 | |
| SCHEMBL5262427 | 0.83 | GPR119 (0.52) | GPR119SMN1; SMN2LMNA | |
| SCHEMBL5264849 | 0.81 | GPR119 (0.52) | GPR119SMN1; SMN2RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | claimed |