Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260100 | 0.89 | GPR119 (0.56) | GPR119SMN1; SMN2 | |
| SCHEMBL389177 | 0.89 | GPR119 (0.56) | GPR119MAPTALDH1A1CTSB | |
| SCHEMBL6250384 | 0.86 | GPR119 (0.44) | GPR119MAPTALDH1A1 | |
| SCHEMBL4706413 | 0.83 | GPR119 (0.37) | GPR119MAPTALDH1A1CTSBBRD4 | |
| SCHEMBL5070687 | 0.81 | GPR119 (0.51) | GPR119MAPTALDH1A1CTSB | |
| SCHEMBL4707378 | 0.79 | MAPT (0.40) | GPR119MAPTALDH1A1SMN1; SMN2CTSB | |
| SCHEMBL389452 | 0.78 | GPR119 (0.71) | GPR119MAPTALDH1A1 | |
| SCHEMBL5263490 | 0.77 | GPR119 (0.45) | GPR119MAPTALDH1A1SMN1; SMN2CTSB | |
| SCHEMBL5262297 | 0.76 | GPR119 (0.60) | GPR119MAPTALDH1A1SMN1; SMN2CTSB | |
| SCHEMBL5267022 | 0.76 | GPR119 (0.47) | GPR119MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599468-B1 | 1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA | ARENA PHARM INC (US) | 2007-10-03 | — | — | EP | claimed |