Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5402989 | 0.72 | MEN1 (0.33) | KDM4E | |
| SCHEMBL1493219 | 0.72 | GLRA1 (0.38) | GLRA1SLC6A9OR51E2KDM4E | |
| Glycine SCHEMBL8525953 | 0.71 | GLRA1 (0.48) | GLRA1SLC6A9OR51E2KDM4E | |
| Glycine SCHEMBL28997747 | 0.67 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2 | |
| Glycine SCHEMBL28673421 | 0.67 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2 | |
| Glycine SCHEMBL28997744 | 0.67 | GLRA1 (0.71) | GLRA1SLC6A9OR51E2 | |
| SCHEMBL52467 | 0.67 | HDAC6 (0.40) | KDM4E | |
| SCHEMBL8587011 | 0.67 | — | — | |
| Tert-Butylamine SCHEMBL29128848 | 0.65 | GLRA1 (0.67) | GLRA1SLC6A9OR51E2KDM4E | |
| Glycine SCHEMBL6162319 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047708-B1 | PEPTIDE CHELATORS THAT PREDOMINATELY FORM A SINGLE STEREOISOMERIC SPECIES UPON COORDINATION TO A METAL CENTER | BRACCO INT BV (NL) | 2007-09-26 | — | — | EP | disclosed |
| US-6334996-B1 | RADIOLABELS FOR TARGETING SPECIFIC DIAGNOSTIC PHARMACEUTICALS | RESOLUTION PHARMACEUTICALS INC. (CA) | 2002-01-01 | — | — | US | disclosed |
| EP-1047708-A1 | PEPTIDE CHELATORS THAT PREDOMINATELY FORM A SINGLE STEREOISOMERIC SPECIES UPON COORDINATION TO A METAL CENTER | RESOLUTION PHARMACEUTICALS INC. (CA) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999033863-A1 | PEPTIDE CHELATORS THAT PREDOMINATELY FORM A SINGLE STEREOISOMERIC SPECIES UPON COORDINATION TO A METAL CENTER | RESOLUTION PHARMACEUTICALS INC. (CA) | 1999-07-08 | — | — | WO | disclosed |