SCHEMBL52467

SCHEMBL52467

CC(C)(C)OC(=O)N(CC(=O)O)C(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC2 Q92769 1/20 0.40
CA14 Q9ULX7 1/20 0.33
TDP1 Q9NUW8 2/20 0.31
EYA2 O00167 1/20 0.31
APP P05067 1/20 0.31
ACE P12821 1/20 0.31
CTSD P07339 1/20 0.31
CTSL P07711 1/20 0.31
CTSB P07858 1/20 0.31
CTSS P25774 1/20 0.31
DGAT1 O75907 1/20 0.30
ADRA1A P35348 2/20 0.30
MEN1 O00255 1/20 0.30
GAA P10253 1/20 0.30
KMT2A Q03164 1/20 0.30
HMGCR P04035 1/20 0.30
CHRM1 P11229 1/20 0.30
TBXA2R P21731 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21570100 0.86 MVD (0.36) HDAC6HDAC1HDAC2CTSLCTSB
SCHEMBL393708 0.81 TDP1 (0.32) TDP1EYA2APPACEADRA1A
SCHEMBL646025 0.80 CA14 (0.38) HDAC6HDAC1HDAC2CA14TDP1
SCHEMBL7342839 0.80 HDAC6 (0.35) HDAC6HDAC1HDAC2
SCHEMBL12928688 0.78 HDAC6 (0.38) HDAC6HDAC1HDAC2CA14DGAT1
SCHEMBL7719558 0.78 HDAC6 (0.38) HDAC6HDAC1HDAC2CA14TDP1
SCHEMBL78691 0.78 CA14 (0.41) HDAC6HDAC1HDAC2CA14TDP1
SCHEMBL2052653 0.77 CA12 (0.41) HDAC6HDAC1HDAC2GAALMNA
SCHEMBL3913731 0.77 HDAC6 (0.33) HDAC6HDAC1HDAC2
SCHEMBL336495 0.77 HDAC6 (0.37) HDAC6HDAC1HDAC2CA14TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 265 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260091024-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD (US) 2026-04-02 US disclosed
US-20260041673-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BIOHAVEN THERAPEUTICS LTD (US) 2026-02-12 US disclosed
US-12472165-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-11-18 US disclosed
US-20250332148-A1 RILUZOLE PRODRUGS AND THEIR USE BIOHAVEN THERAPEUTICS LTD (US) 2025-10-30 US disclosed
US-12295942-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-05-13 US disclosed
US-12213965-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (VG) 2025-02-04 US disclosed
US-12005047-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2024-06-11 US disclosed
US-12005046-B2 Riluzole prodrugs and their use BIOHAVEN THERAPEUTICS LTD. (US) 2024-06-11 US disclosed
US-20240091205-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE BEETLEJUICE SA LLC, AS PURCHASER AGENT 2024-03-21 US disclosed
US-20240082417-A1 PROTEIN-POLYMER DRUG CONJUGATES ASANA BIOSCIENCES, LLC 2024-03-14 US disclosed
US-6239125-B1 ANTIVIRAL AGENTS AGAINST HERPES VIRUSES. BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2001-05-29 US disclosed
US-6194143-B1 MEASUREMENT ACTIVITY BY MONITORING SUBSTRATE CLEAVAGE BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2001-02-27 US disclosed
EP-1021404-A1 AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2000-07-26 EP disclosed
US-6030972-A 2- OR 5-AMINOMETHYL,2- OR 5-CYANOPYRIMIDINES AS INTERMEDIATES OF ANTICOAGULANTS IN EXTRACORPOREAL CIRCULATION (HEART-LUNG MACHINE, HEMODIALYSIS) BASF AKTIENGESELLSCHAFT (DE) 2000-02-29 US disclosed
WO-1999018071-A1 AZETIDINONE DERIVATIVES FOR THE TREATMENT OF HCMV INFECTIONS BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 1999-04-15 WO disclosed
EP-0873356-A1 NOVEL DIPEPTIDE AMIDINES AS THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1998-10-28 EP disclosed
US-5646121-A CYTOMEGALOVIRUSES BAYER AKTIENGESELLSCHAFT (DE) 1997-07-08 US disclosed
WO-1996025426-A1 NOVEL DIPEPTIDE AMIDINES AS THROMBIN INHIBITORS BASF AKTIENGESELLSCHAFT (DE) 1996-08-22 WO disclosed
EP-0646597-A1 New pseudopeptides with antiviral activity containing valine BAYER AG (DE) 1995-04-05 EP disclosed
EP-0443573-A2 HIV protease inhibitors containing derived amino acids BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1991-08-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260091024-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE IL6ST, GFRA3, GFRA1 HDAC6 562/4885HDAC1 325/4885HDAC2 715/4885
US-12005046-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 HDAC6 477/4885HDAC1 145/4885HDAC2 536/4885
US-12005047-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 HDAC6 477/4885HDAC1 145/4885HDAC2 536/4885
US-20260041673-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE GFRA3, IL6ST, GFRA1 HDAC6 566/4885HDAC1 328/4885HDAC2 747/4885
US-12472165-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 HDAC6 477/4885HDAC1 145/4885HDAC2 536/4885
US-12295942-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 HDAC6 477/4885HDAC1 145/4885HDAC2 536/4885
US-20240091205-A1 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE APEH, UGT1A9, ALDH3A1 HDAC6 582/4885HDAC1 265/4885HDAC2 731/4885
US-20250332148-A1 RILUZOLE PRODRUGS AND THEIR USE APEH, ALDH1A2, UGT1A9 HDAC6 477/4885HDAC1 145/4885HDAC2 536/4885
US-12213965-B2 Riluzole prodrugs and their use APEH, ALDH1A2, UGT1A9 HDAC6 477/4885HDAC1 145/4885HDAC2 536/4885
US-20240082417-A1 PROTEIN-POLYMER DRUG CONJUGATES PBRM1, STAMBP, TSPO HDAC6 846/4885HDAC1 1398/4885HDAC2 2735/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.