Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL28462226 | 0.98 | ALDH1A1 (0.59) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL28462227 | 0.98 | ALDH1A1 (0.59) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL27844305 | 0.87 | ALDH1A1 (0.68) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL29710686 | 0.87 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL28142303 | 0.87 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL5874241 | 0.87 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL21535 | 0.87 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL28261411 | 0.87 | ALDH1A1 (0.74) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL28001767 | 0.86 | ALDH1A1 (0.61) | ALDH1A1KDM4EALOX12MEN1KMT2A | |
| Quinoline SCHEMBL3914666 | 0.85 | ALDH1A1 (0.71) | ALDH1A1KDM4EALOX12MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101948429-B | 1-methyl-7H-indene[1, 2-b]quinolinetrifluoromesylate-7-(4-dimethylamino) benzyl alkene derivant and preparation thereof | UNIV SOOCHOW | 2012-07-18 | — | — | CN | claimed |
| CN-101948429-A | 1-methyl-7H-indene[1, 2-b]quinolinetrifluoromesylate-7-(4-dimethylamino) benzyl alkene derivant and preparation thereof | UNIV SUZHOU | 2011-01-19 | — | — | CN | claimed |
| US-5220106-A | Organic non-quaternary clathrate salts for petroleum separation | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1993-06-15 | — | — | US | claimed |
| CN-111909085-B | Fluorescent probe for detecting sulfur dioxide derivative, detection object, preparation method and application | 衡阳师范学院 | 2023-07-18 | — | — | CN | disclosed |
| CN-109851554-B | Method for preparing trifluoromethanesulfonic acid-6-quinoline ester derivative | 中国科学院大连化学物理研究所 | 2022-05-17 | — | — | CN | disclosed |
| CN-111909085-A | Fluorescent probe for detecting sulfur dioxide derivative, detector, preparation method and application | 衡阳师范学院 | 2020-11-10 | — | — | CN | disclosed |
| CN-107709393-A | Reaction product containing urethane group and urea groups | 毕克化学有限公司 | 2018-02-16 | — | — | CN | disclosed |
| CN-101948382-B | Synthetic method of 2-(4-alkyl substituted benzoyl) phenylformic acid | UNIV ZHEJIANG TECHNOLOGY | 2013-06-05 | — | — | CN | disclosed |
| CN-101948382-A | Synthetic method of 2-(4-alkyl substituted benzoyl) phenylformic acid | UNIV ZHEJIANG TECHNOLOGY | 2011-01-19 | — | — | CN | disclosed |
| EP-1496896-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| US-7223738-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2007-05-29 | — | — | US | disclosed |
| US-20050222155-A1 | Inhibitors of akt activity | MERCK SHARP & DOHME CORP. | 2005-10-06 | — | — | US | disclosed |
| EP-1496896-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003086394-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |
| EP-0562815-A1 | Aromatic hydrocarbons separation from aromatic/non-aromatic mixtures | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1993-09-29 | — | — | EP | disclosed |
| US-5220106-A | Organic non-quaternary clathrate salts for petroleum separation | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222155-A1 | Inhibitors of akt activity | AKT1, AKT2, AKT3 | ALDH1A1 3399/4885KDM4E 1347/4885ALOX12 4445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.