Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 7/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.45 |
| ▸ | CDK1 | P06493 | 7/20 | 0.45 |
| ▸ | CDK4 | P11802 | 7/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.45 |
| ▸ | CCND1 | P24385 | 7/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.45 |
| ▸ | CDK2 | P24941 | 7/20 | 0.45 |
| ▸ | CCND2 | P30279 | 7/20 | 0.45 |
| ▸ | CCND3 | P30281 | 7/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262559 | 0.84 | MAPT (0.48) | MAPTSMN1; SMN2ALDH1A1LMNAPDE4B | |
| SCHEMBL5262267 | 0.82 | MAPT (0.43) | MAPTSMN1; SMN2ALDH1A1LMNAPDE4B | |
| SCHEMBL6188570 | 0.77 | ALDH1A1 (0.51) | MAPTSMN1; SMN2ALDH1A1LMNAPDE1A | |
| SCHEMBL5260194 | 0.72 | CCNE2 (0.53) | CCNB2CCNE2CDK1CDK4CCNB1 | |
| SCHEMBL587425 | 0.71 | PDE4B (0.60) | MAPTSMN1; SMN2ALDH1A1LMNAPDE4B | |
| SCHEMBL582644 | 0.71 | PDE4B (0.60) | MAPTSMN1; SMN2ALDH1A1LMNAPDE4B | |
| SCHEMBL30644829 | 0.71 | ALDH1A1 (0.49) | MAPTSMN1; SMN2ALDH1A1LMNAPDE4B | |
| SCHEMBL2792459 | 0.71 | ALDH1A1 (0.49) | MAPTSMN1; SMN2ALDH1A1LMNAPDE4B | |
| SCHEMBL5262025 | 0.70 | CCNE2 (0.55) | CCNE2CCNE1CDK2MAPTSMN1; SMN2 | |
| SCHEMBL6188594 | 0.70 | ALDH1A1 (0.45) | MAPTSMN1; SMN2ALDH1A1LMNAPDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043998-B1 | USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDANT KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-03-07 | — | — | EP | disclosed |