Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE1A | P54750 | 3/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262559 | 0.87 | MAPT (0.48) | MAPTALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL5260494 | 0.82 | CCNB2 (0.45) | MAPTALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL6188570 | 0.80 | ALDH1A1 (0.51) | MAPTALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL583310 | 0.78 | ADORA1 (0.55) | MAPTALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL583304 | 0.78 | PDE4B (0.54) | PDE4BADORA1 | |
| SCHEMBL583294 | 0.77 | PDE4B (0.50) | MAPTALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL582502 | 0.76 | PDE4B (0.62) | PDE4BADORA1 | |
| SCHEMBL583449 | 0.76 | PDE4B (0.49) | PDE4BADORA1 | |
| SCHEMBL583448 | 0.76 | PDE4B (0.49) | PDE4BADORA1 | |
| SCHEMBL15130259 | 0.74 | NPBWR1 (0.45) | ALDH1A1SMN1; SMN2NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1043998-B1 | USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDANT KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-03-07 | — | — | EP | disclosed |