Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6248381 | 0.74 | ALDH1A1 (0.40) | KDM4EHPGDLRRK2MAOAMAOB | |
| SCHEMBL2260175 | 0.73 | TNKS (0.45) | POLBHTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL29609239 | 0.73 | TNKS (0.45) | POLBHTR2AHTR2CHTR2BMEN1 | |
| Hydrochloric Acid SCHEMBL16600202 | 0.72 | TNKS (0.44) | POLBHTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL29556824 | 0.71 | CDC7 (0.40) | ALDH1A1POLBGSK3BNPSR1 | |
| SCHEMBL8279014 | 0.71 | CDC7 (0.40) | ALDH1A1POLBGSK3BNPSR1 | |
| SCHEMBL29384445 | 0.69 | TNKS (0.45) | KDM4EHPGDALDH1A1POLBHTR2A | |
| SCHEMBL1828877 | 0.69 | TNKS (0.45) | KDM4EHPGDALDH1A1POLBHTR2A | |
| SCHEMBL3432668 | 0.69 | LIG1 (0.39) | KDM4EHPGDLRRK2MAOAMAOB | |
| SCHEMBL20469127 | 0.68 | TNKS (0.44) | KDM4EHPGDALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836183-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | Galileo Pharmaceuticals, Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006065686-A2 | SPIRO DERIVATIVES AS LIPOXYGENASE INHIBITORS | GALILEO PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | disclosed |