Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.42 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1858932 | 0.82 | PIK3CD (0.51) | ACHEPIK3CDPIK3CACYP1A2CYP3A4 | |
| SCHEMBL7519805 | 0.79 | KMT2A (0.59) | ACHECYP1A2CYP3A4CLK4CYP2D6 | |
| SCHEMBL4240648 | 0.75 | PKM (0.49) | ACHECD274PKMCYP1A2CYP3A4 | |
| SCHEMBL4240340 | 0.73 | MAPT (0.58) | CD274PKMPIK3CDALDH1A1LMNA | |
| SCHEMBL7525975 | 0.72 | KMT2A (0.56) | ACHEPKMCYP1A2CYP3A4CLK4 | |
| SCHEMBL25203384 | 0.71 | MAP3K8 (0.48) | ACHEPIK3CDPIK3CACYP1A2CYP3A4 | |
| SCHEMBL30437399 | 0.71 | MAP3K8 (0.48) | ACHEPIK3CDPIK3CACYP1A2CYP3A4 | |
| SCHEMBL2696438 | 0.70 | SIGMAR1 (0.42) | ACHEPIK3CDPIK3CAALDH1A1ACP1 | |
| SCHEMBL4246619 | 0.68 | CYP1A2 (0.51) | ACHECD274PKMCYP1A2CYP3A4 | |
| SCHEMBL15872032 | 0.67 | KMT2A (0.59) | ACHECYP1A2CYP3A4CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578424-A4 | SUBSTITUTED 1-BENZOYL-3-CYANO-PYRROLO 1,2-A| QUINOLINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | CYTOVIA INC (US) | 2007-08-08 | — | — | EP | claimed |
| EP-1578424-A2 | SUBSTITUTED 1-BENZOYL-3-CYANO-PYRROLO 1,2-A] QUINOLINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | Cytovia, Inc. (US) | 2005-09-28 | — | — | EP | claimed |
| WO-2004055163-A2 | SUBSTITUTED 1-BENZOYL-3-CYANO-PYRROLO[1,2-A]QUINOLINES | CYTOVIA, INC. (US) | 2004-07-01 | — | — | WO | claimed |