Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 11/20 | 0.52 |
| ▸ | AKT2 | P31751 | 9/20 | 0.52 |
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260840 | 0.83 | AKT1 (0.68) | AKT1AKT2AKT3 | |
| SCHEMBL5308375 | 0.81 | AKT1 (0.80) | ALDH1A1MAPTAKT1AKT2AKT3 | |
| SCHEMBL5305225 | 0.81 | AKT1 (0.80) | ALDH1A1MAPTAKT1AKT2AKT3 | |
| SCHEMBL5257804 | 0.76 | AKT1 (0.56) | AKT1AKT2AKT3 | |
| SCHEMBL26573334 | 0.75 | ALDH1A1 (0.71) | ALDH1A1MAPTHPGDKDM4ELMNA | |
| SCHEMBL2439564 | 0.74 | AKT1 (0.49) | AKT1AKT2AKT3 | |
| SCHEMBL26573333 | 0.73 | ALDH1A1 (0.68) | ALDH1A1MAPTHPGDKDM4ELMNA | |
| SCHEMBL2439485 | 0.73 | AKT1 (0.50) | AKT1AKT2AKT3 | |
| SCHEMBL26573326 | 0.73 | ALDH1A1 (0.65) | ALDH1A1MAPTHPGD | |
| SCHEMBL26573349 | 0.73 | ALDH1A1 (0.65) | ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496896-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | claimed |
| EP-1496896-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | claimed |
| WO-2003086394-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | claimed |
| EP-1496896-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1496896-A1 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003086394-A1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2003-10-23 | — | — | WO | disclosed |