Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5336202 | 0.98 | MAOB (0.52) | MAOBRECQLS1PR2S1PR1S1PR3 | |
| SCHEMBL8899345 | 0.86 | RECQL (0.64) | MAOBRECQLS1PR2S1PR1S1PR3 | |
| SCHEMBL11291036 | 0.84 | MAOB (0.57) | MAOBRECQLGFERMGLLCA2 | |
| SCHEMBL27280507 | 0.82 | MGLL (0.68) | S1PR2S1PR1S1PR3MGLLCA2 | |
| SCHEMBL23322490 | 0.81 | S1PR2 (0.65) | S1PR2S1PR1S1PR3MGLLCA2 | |
| SCHEMBL15613965 | 0.81 | S1PR2 (0.60) | S1PR2S1PR1S1PR3MGLLCA2 | |
| SCHEMBL1334284 | 0.81 | HDAC3 (0.50) | S1PR2S1PR1S1PR3MGLLCA2 | |
| SCHEMBL3139486 | 0.81 | MGLL (0.51) | S1PR2S1PR1S1PR3MGLLCA2 | |
| SCHEMBL9051355 | 0.81 | IGF1R (0.50) | S1PR2S1PR1S1PR3MGLLCA2 | |
| SCHEMBL3129672 | 0.81 | MGLL (0.47) | S1PR2S1PR1S1PR3MGLLCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836161-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006085149-A2 | METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2006-08-17 | — | — | WO | disclosed |