Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29935946 | 0.79 | KDM5A (0.41) | KMT2AL3MBTL1MEN1KDM4ENPC1 | |
| SCHEMBL10063578 | 0.79 | KDM5A (0.41) | KMT2AL3MBTL1MEN1KDM4ENPC1 | |
| SCHEMBL6652043 | 0.73 | ALDH1A1 (0.38) | L3MBTL1KDM4ENPSR1MAPTHPGD | |
| SCHEMBL30405634 | 0.73 | FEN1 (0.40) | KMT2AL3MBTL1MEN1KDM4EHSP90AA1 | |
| SCHEMBL28098681 | 0.70 | MAPT (0.51) | L3MBTL1KDM4EMAPTTP53 | |
| SCHEMBL19126584 | 0.68 | MAPT (0.50) | KDM4EMAPT | |
| SCHEMBL3095175 | 0.68 | POLB (0.42) | KMT2AL3MBTL1MEN1KDM4ENPC1 | |
| SCHEMBL31298640 | 0.68 | ELANE (0.38) | L3MBTL1FEN1ELANEGABRA1GABRG2 | |
| SCHEMBL29956951 | 0.67 | FEN1 (0.45) | KMT2AL3MBTL1MEN1KDM4ENPC1 | |
| SCHEMBL29935498 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814883-A1 | BICYCLIC INHIBITORS OR RHO KINASE | Vertex Pharmaceuticals Incorporated (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006058120-A1 | BICYCLIC INHIBITORS OR RHO KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-06-01 | — | — | WO | disclosed |