Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PLEC | Q15149 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10212024 | 0.85 | MEN1 (0.40) | MEN1KMT2AMAPTPOLBCYP1A2 | |
| SCHEMBL8852131 | 0.79 | MGAM (0.49) | TDP1MEN1KMT2AMAPTGABRA1 | |
| SCHEMBL28524128 | 0.79 | KDM4E (0.41) | MEN1KMT2AMAPTCYP1A2PKM | |
| SCHEMBL18850241 | 0.78 | TDP1 (0.58) | TDP1MEN1KMT2AMAPTPOLB | |
| SCHEMBL8515582 | 0.78 | CYP4F2 (0.38) | TDP1MEN1KMT2AMAPTPOLB | |
| SCHEMBL19050195 | 0.75 | AKR1B1 (0.54) | TDP1MEN1KMT2AMAPTPOLB | |
| SCHEMBL21462042 | 0.74 | GABRA1 (0.48) | TDP1MEN1KMT2AMAPTPOLB | |
| SCHEMBL426942 | 0.73 | PTGS2 (0.42) | MEN1KMT2AMAPTPOLBCYP1A2 | |
| SCHEMBL19138018 | 0.73 | PTGS2 (0.47) | TDP1MEN1KMT2AMAPTPOLB | |
| SCHEMBL6390178 | 0.72 | AKR1B1 (0.55) | TDP1MAPTCYP1A2GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786822-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024517-A1 | FUSED TRICYCLIC DERIVATIVES FOR THE TREATMENT OF PSYCHOTIC DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |