Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 14/20 | 0.39 |
| ▸ | CDK2 | P24941 | 14/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 12/20 | 0.39 |
| ▸ | AURKA | O14965 | 6/20 | 0.39 |
| ▸ | PLK1 | P53350 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 4/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.36 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.36 |
| ▸ | CDK4 | P11802 | 3/20 | 0.36 |
| ▸ | CCND3 | P30281 | 3/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL526117 | 0.82 | HSP90AA1 (0.43) | KDM4EALDH1A1POLBHSP90AA1MAP3K14 | |
| SCHEMBL525745 | 0.81 | TTK (0.56) | KDM4EALDH1A1CCNA2CDK2CCNA1 | |
| SCHEMBL525744 | 0.80 | CCNA2 (0.40) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL525472 | 0.78 | CCNA2 (0.35) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL3503440 | 0.73 | CCNA2 (0.65) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL3589153 | 0.70 | CCNA2 (0.65) | CCNA2CDK2CCNA1TTKPIM1 | |
| SCHEMBL525847 | 0.70 | CDK2 (0.73) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL31060273 | 0.70 | CDK2 (0.49) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL526058 | 0.70 | CDK2 (0.49) | CCNA2CDK2CCNA1AURKAPLK1 | |
| SCHEMBL1894800 | 0.69 | MAP3K14 (0.41) | KDM4EALDH1A1POLBHSP90AA1MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9333205-B2 | Isoxazolo-quinazolines as modulators of protein kinase activity | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-05-10 | — | — | US | disclosed |
| EP-2598508-B1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-04-22 | — | — | EP | disclosed |
| US-20130143896-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-06-06 | — | — | US | disclosed |
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143896-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | CSNK1A1, RPS6KA1, CSNK2A1 | KDM4E 3816/4885ALDH1A1 3745/4885POLB 2408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.